112 care leavers aged 18 to 24 died last year, according to a government-commissioned review – that's three to four times the rate of their peers. Sky’s @NickMartinSKY has been following the journeys of people leaving the care system for many years. Joining @skynewsniall, he tells us about the challenges young people face when leaving care and shares the stories of those with first-hand experience of living in care and what changes could help them when leaving the system. Anyone feeling emotionally distressed or suicidal can call Samaritans for free on 116 123 or visit in the UK. In the US, call the Samaritans branch in your area or 1 (800) 273-TALK. Listen to This Is Why:

BREAKING: $MRNA is up 112% in premarket after the first ever positive Phase 3 results for a personalized cancer vaccine. Moderna and Merck ran the trial together. $MRK is also up 9% on the news. Doctors take a sample of the patient's tumour and read its DNA. Every tumour has its own set of mutations. They then build a custom mRNA shot for that one person, which teaches the immune system what to hunt for. The trial covered 1,137 melanoma patients. Those who got the shot alongside Keytruda saw the cancer come back less often than those who got Keytruda alone. No new safety problems were found. Keytruda is the current standard treatment and brought Merck $8 billion in a single quarter. This is the first time anything has improved on it. The shot does not replace Keytruda, it is added on top. Nine trials are running across other cancers including lung, bladder and kidney.

🚀 Codex 0.112.0 is out! 🔌 @plugin mentions pull in plugin context 🤖 TUI model picker shows latest models 🔒 Permission profiles merge into per-turn sandbox 💾 JS REPL bindings persist through failed cells Changelog: