As a kid, Mark Cuban sold stamps door-to-door and then gave disco lessons to help pay his way through Indiana University. Cuban first built streaming pioneer Broadcast. com with Todd Wagner in 1995 and sold it to Yahoo for $5.7 billion in 1999. Today, he owns a minority stake in the NBA's Dallas Mavericks and is cofounder of Cost Plus Drugs, which he launched in January 2022 with the aim of lowering prescription drug prices. See where the shark ranks among the top innovators on the #Forbes250# list. (Photo: Guerin Blask for Forbes)