This week in epigenetic and aging insights: 1. the oldest land animal, 194 years 2. why small dogs live longer than big ones 3. Why commercial epigenetic ("biological") clocks are problematic 4. What epigenetic clocks are actually measuring

Next step: Longevity and Rejuvenation. We are almost there. Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA. The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.