Vijay Pande — who left a16z's roughly $4 billion biotech practice last year to start the much smaller, AI-native VZVC — talks about why biology is finally shifting from a "discovery" science to an "engineering" one, why clinical trials are still brutally

Nimble Commander is a free dual-pane file manager for macOS that brings back fast keyboard-driven navigation, blending classic file manager speed with a modern Mac feel. Explore it here:

Just landed: /diff is now a persistent pane that you can scroll and click. It updates in real-time. For the times when you want to see the code without having to switch windows. Enjoy!

You can pop out any pane in the Claude Code desktop app into its own window. Drag the diff or terminal to a second screen while Claude keeps working in the main window, then dock it back whenever you want. You can also run sessions side-by-side or stacked.

I made a video demonstrating some of the smaller recent improvements to the Hermes Desktop app: - A single composer for multiple panes. Hover over the pane to highlight it, enter a prompt, and it goes in that one. The model picker also reflects the pane that is active - Right click profiles to open a new app window with that profile active - New skills and plugins UI and catalog in the Capabilities tab Check it out!

Two more ships this week for the ChatGPT Desktop in-app browser! Media Tabs: Find your music or meeting without hunting through threads! All tabs with audio/video activity are now grouped in one menu in the side pane. (s/o @ngu_khoi @schwa23) Zero-state autocomplete: Jump back into your browser work faster. Just click the empty URL bar to see your most recently visited pages. (s/o @olivertepman) Let us know what you think, especially if you’re using the IAB as your daily driver. We are still working on bringing extension support safely to the IAB, thanks for your patience!

tmux-bridge is a CLI that lets any AI agent read, type, and send keys to any tmux pane, enabling cross-agent workflows. - One-command install sets up tmux, config, and the bridge CLI - `tmux-bridge read/type/keys` controls any pane by label or target - Claude Code can prompt Codex in the next pane and get replies back - Option-key bindings and mouse support for keyboard-driven navigation Explore it here:

as we keep moving towards personal software & owning the tokenflow, the first thing to be tackled is the "personal harness" - implemented as "ai inside an app" vs "app inside ai" (i.e. the inversion of "codex has browser pane" - "app in your browser has codex inside of it") fx by vercel is act 1

🎃 Kaku is a fast, out-of-the-box terminal built for AI coding. Two new releases: faster startup, prompts, and AI chat, plus jump-to-any-pane in split tabs, cleaner renaming and selection, and more reliable session restore.