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The HPV vaccine has reduced cervical cancer deaths to near zero in key age groups. A major study in England has shown that girls who received the human papillomavirus (HPV) vaccine at ages 12 to 13 now face an almost nonexistent risk of dying from cervical cancer before age 30. These results offer the strongest evidence to date that the vaccine does more than prevent infections and precancerous lesions, it is actively saving lives. Between 2020 and 2024, not a single cervical cancer death was recorded among women aged 20 to 24 in England. Scientists estimate that approximately 23 deaths would have occurred in this group without the national HPV vaccination program. The program began offering the vaccine to schoolgirls in 2008. Since then, researchers calculate it has already prevented around 200 cervical cancer deaths in England, with far greater numbers expected as vaccinated generations age. HPV is a very common virus transmitted through intimate skin-to-skin contact. While most infections resolve naturally, persistent cases can lead to cervical cancer. In fact, HPV is responsible for roughly 99 percent of all cervical cancer cases. Experts note that this sharp decline in deaths is only the start. As more vaccinated individuals reach the peak ages for cervical cancer, the impact is projected to increase significantly. Vaccination is not a complete solution on its own. Regular cervical screening continues to play a vital role, as the vaccine does not protect against every cancer-causing HPV strain. The World Health Organization aims to eliminate cervical cancer as a public health problem. These promising results suggest that goal is achievable if high vaccination coverage and screening programs are maintained. [Sasieni P, Falcaro M. Cervical cancer mortality trends following HPV vaccination in England, 2001–24: an analysis of population-based mortality data. The Lancet. Published online June 17, 2026. doi:10.1016/S0140-6736(26)00918-9]