📢 BrownDust2 x Anime Expo 2026 Booth Activities ✨ BrownDust2 is coming to Anime Expo 2026! Come visit us and celebrate our 3rd anniversary with us! 🚢🎉 📍 Location Anime Expo 2026 – LA Convention Center West Hall, Booth WH 3524 🌟 First Class Passenger Chill Zone For our Leviathan “First Class Passengers” with Achievement Level 46 or higher, we’ve prepared a special rest area! Relax and enjoy: - Massage chairs - Merch delivery service - Exclusive giveaway merch 📸 Cosplayer Selfie Time Our 3rd anniversary characters will be brought to life by amazing cosplayers! Take a selfie with our cosplayers and receive special merch! 🎁 Featuring: Minhanna: @hannamin914 Mio: @mio_love_cos Reina: @reiinacos Jaenakos: @jaenakos ✍️ Meet the Dev Team Starting with Anime Expo, the BrownDust2 dev team is heading out to meet our North American fans! We’re preparing special programs, including: - Developer autograph sessions - Fan meeting / Q&A sessions Application details will be shared later through our community channels, so stay tuned! 🛍️ Exclusive 3rd Anniversary Merch We’re preparing a variety of items, including: - 3rd anniversary themed merch - Popular fan-favorite merch - Event-exclusive goodies - Merch lineups will be revealed one by one, so don’t miss them! 🎁 Booth Visit Rewards Just stopping by the booth? We’ve got plenty of giveaway merch ready for you too! Come celebrate BrownDust2’s 3rd anniversary with us at Anime Expo 2026. We can’t wait to see you there! ✨ #BrownDust2# #AnimeExpo2026# #AX2026# #BrownDust2_3rdAnniversary#

【BrownDust2 at Anime Expo 2026】 All aboard, Adventurers! ✨ BrownDust2 is heading to Anime Expo 2026 with a booth fully themed around our 3rd Anniversary “Summer Cruise”! 🌊 📍 LA Convention Center - West Hall #3524# 📅 July 2–5 Join us on-site for exciting activities, special experiences, and exclusive prizes—we can’t wait to see you there! Set sail with BrownDust2 🌊 #BrownDust2# #BD2AX2026#

Hear me out. On paper COMMIT is a "Positive" trial. It is also a spectacular demonstration that Atezolizumab monotherapy should never be used for metastatic MSI-H CRC (we can talk about adjuvant). COMMIT was a randomized first-line study in metastatic MSI-H/dMMR CRC. It began as a 3-arm trial of: • mFOLFOX6/bevacizumab (this sucks) • atezolizumab alone • mFOLFOX6/bevacizumab/atezolizumab After KEYNOTE-177 changed the standard of care, the chemotherapy-only arm closed after 20 patients. The trial continued with 82 patients randomized between atezo alone and the four-drug combination. The headline is that adding FOLFOX/bevacizumab to atezo improved PFS: HR 0.42 Median PFS: 24.5 vs 5.3 months ORR: 86% vs 46% Primary progression: 2.8% vs 32.4% The truth is Atezolizumab PALES in comparison to its contemporary PD1/PDL1 agents in this setting. Single-agent atezo: 12-month PFS 35% 24-month PFS 32% For comparison: Pembrolizumab in KEYNOTE-177: 12-month PFS 55% 24-month PFS 48% Nivolumab in CheckMate 8HW: 12-month PFS 63% 24-month PFS 56% This is not evidence that every patient with metastatic MSI-H CRC needs chemotherapy, bevacizumab, and immunotherapy. It is evidence that NO ONE SHOULD BE USING ATEZOLIZUMAB IN METASTATIC MSI-H CRC. And now, drumroll please… The only positive randomized adjuvant immunotherapy strategy in stage III dMMR colon cancer is ATOMIC: FOLFOX + atezolizumab. That makes COMMIT more than a roast. It raises a important question about ATOMIC. Should we be using Atezolizumab in the adjuvant setting? Do we need to be giving chemotherapy here? Looking forward to what others make of this but this is the real question. @TheGutOncLab @OncoAlert @oncodaily