Throughout civilization, the greatest periods of economic and societal progress have come when humanity unlocked a new source of productive capacity. Our new initiative, Pioneering Abundance, is pursuing the next great unlock. Read our latest perspective:

“We try and find problems that no one else is going to solve, and then solve them.” Head of @Flagship_PI Matt Davis on how PI applies Flagship's whitespace approach to AI by pursuing what no one else will. Watch Matt’s full 3 Questions:

For thousands of years, using massive amounts of water to flood rice fields looked like the price of feeding the world. It wasn't a law of nature — just a workaround for a problem we couldn't yet solve biologically. In our latest post on The Labs Report, Flagship’s Ignacio Martinez and Alec Asbridge explore what changes once biology becomes readable, and how our Pioneering Abundance initiative takes an ecosystem approach to turn those insights into real solutions. Read:

“Solving the structure of the ribosome” was once a joke — a shorthand for a structural problem ambitious enough to sound absurd. So we chose it as a test. In 36 seconds on a single GPU, LightFold co-folds the E. coli 70S ribosome assembly: 11,000 residues and nucleotides, comprising nearly 150,000 atoms. At ~6,400x speedup and 48x less memory usage than Fold-CP-enabled models, LightFold begins to move long-context prediction from a computational feat to a drug-development tool. Learn more:

Big news today: @Envestnet_ entered a definitive agreement to acquire @Vestmark! I’ve been involved in dozens of exits, but this one is very close to my heart. I started Vestmark with my fraternity brothers (and my actual brother), writing the first few lines of code myself by hand, all the way through today where the company supports 2T+ in assets, 5+ million accounts, and is leading the way with cutting edge AI solutions in a heavily regulated space. I’m so proud of the 100s of incredible individuals who made it their life mission to build Vestmark, working alongside me, and then carrying the torch beyond my time as a 9-9-6 founder. We only got here because of you! I’m also grateful for all of those who worked so diligently to unite these two great companies: the employees, the leadership teams, the respective boards, and an extra shoutout to Karl Roessner and Colin Motley. Looking ahead, I’m comforted knowing Vestmark will be in the extremely capable hands of Chris Todd, a trusted, seasoned operator in the space. This is just the team to maintain Vestmark’s trajectory! As this chapter comes to a close, I’ve got a lot to look forward to. I’m back to working deep in the code, building something new and close to my MIT roots. Stay tuned for the launch! -Dave Blundin The deal is expected to close in the fourth quarter, subject to customary closing conditions. Press Release here:

We're teaming up with @AnthropicAI and @modal to host a Computational Biology Hackathon. Bring a protein sequence, gene set, or microscopy dataset — leave with an agentic tool built on Modal x Claude Science. Sept 22 | 9AM–7:30PM | Cambridge, MA RSVP:

Today, Flagship launches Pioneering Abundance—a new initiative focused on reimagining how we produce the resources that power our world. For decades, we’ve built around the constraints of scarcity. Now, biology, AI, and deep tech are opening a different path: creating abundance. Learn more: #BiggerLeaps#

The gap between when disease begins and when we can detect it is closing. Flagship Origination Partner Scott Lipnick shares what happens next, in his recent perspective for The Labs Report:

AI is beginning to reveal nature’s patterns, helping us recognize connections, ask better questions, and uncover possibilities we couldn't have reached on our own. Polyintelligence — the synthesis of human, machine, and nature's intelligence — is unlocking new forms of problem solving and creativity. So, what breakthroughs become possible when we can finally understand — and build with — nature’s intelligence? @JCoolScience @AnthropicAI @AvakK @afzelius_lovisa @Prologue_Med @bramaccimmyt @CIMMYT