Flagship Pioneering
@FlagshipPioneer
We are a biotechnology company that invents and builds platform companies that change the world.
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Our data deep dives show the science behind building companies within Flagship Labs, from co-folding large proteins to new modalities that look like biologics but can’t be degraded by proteases or recognized by the immune system.
Catch up in The Labs Report:
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Flagship announces the formation of Etcelera, a new company that brings together the platforms of @cellaritybio, @Empress_Tx and @etiome with Flagship’s @Flagship_PI capabilities to scale causal intelligence in human biology.
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"It's really hard to envision extraordinary outcomes unless you do unreasonable-seeming things."
In a new @business feature, Flagship Founder & CEO @NoubarAfeyan reflects on Flagship’s approach to company creation: pursuing ambitious scientific questions early, building the capabilities to test them, and creating companies around discoveries that can reshape what is possible.
It's the approach that's led to over 130 companies, including #FlagshipFounded# @moderna_tx, @generate_biomed, @SailBiomeds, and more. #BiggerLeaps#
Read the full story here:
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Flagship Founder and CEO @NoubarAfeyan joined @LizClaman on @FoxBusiness’ The Claman Countdown to discuss the Phase 3 trial data for @Merck and #FlagshipFounded# @moderna_tx’s mRNA-based therapy for melanoma.
The results mark the first positive Phase 3 trial for an individualized neoantigen therapy and for an mRNA-based cancer therapy — a major milestone for personalized cancer treatment.
Watch the full conversation here:
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Today, #FlagshipFounded# @moderna_tx, along with @Merck released positive results from its Phase 3 INTerpath-001 study for intismeran autogene, an investigational mRNA-based individualized neoantigen therapy, plus KEYTRUDA®, in patients with completely resected stage IIB-IV melanoma.
Data will be presented at the 2026 European Society for Medical Oncology (@myESMO) Congress. #BiggerLeaps#
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Pioneering starts before there’s proof. Avak Kahvejian, President of Flagship Labs, reflects on taking a risk on an idea no one knew would work, and how eRNA went from a biological curiosity to a strategic collaboration between #FlagshipFounded# @SailBiomeds and @JNJNews:
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Flagship Founder and CEO @NoubarAfeyan has been named to @Forbes’ list of America’s Greatest Optimists (#17#).
At Flagship, we call it paranoid optimism: the balance between believing deeply in what’s possible while constantly challenging assumptions, stress testing ideas, and being prepared for the unexpected. It’s a mindset that helps us tackle humanity’s toughest challenges.
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Optimism is at the heart of the American dream.
In that spirit Forbes is recognizing the country’s 250 Greatest Living Optimists. These are founders who took a big risk on new possibilities, investors who prioritize long-term value over short-term gain, market-minded philanthropists and educational pioneers. #Forbes250#
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Illustration: Lina Jaradat for Forbes; Photos: Guerin Blask for Forbes, Cody Pickens for Forbes, Jamel Toppin for Forbes, Martin Schoeller for Forbes, Tim Pannell for Forbes
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How a T cell killing a B cell in a petri dish turns into a strategic collaboration between J&J and #FlagshipFounded# @SailBiomeds to develop in vivo CAR-T: @AvakK, President of Flagship Labs and Co-Founder of Sail Biomedicines, reflects on the origins and potential impact of eRNA-based therapies. Read more here:
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Armen Mkrtchyan never journaled until he started talking through his day with iris chat. Now, his journal doubles as a thought partner.
Hear how @irislabsinc is helping people thrive, and learn about the science behind iris chat in the latest episode of The Labs Report:
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What is the Flagship Fellowship?
Discover a 12-week, paid summer program that pushes fellows to stretch beyond existing scholarship and embrace uncertainty while working side-by-side with our origination teams. Fellows use Flagship’s company-creation process and AI tools to generate and refine ideas that have the potential to become breakthrough companies.
Learn more about the Fellowship at an upcoming info session:
📅 October 15, 10–11 AM EDT
📅 November 10, 1–2 PM EDT
📅 December 7, 11 AM–12 PM EDT
Sign up here:
#FlagshipFellowship# #WeAreFlagship#
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Flagship Founder and CEO @NoubarAfeyan joined @Bloomberg's @flacqua during the @BBGNewEconomy Forum in New Delhi to discuss how AI is changing our understanding of disease, how technology can power the next wave of breakthroughs, and what’s next for @moderna_tx and Merck’s mRNA-based cancer therapy after recent Phase 3 trial results.
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We recently shared a deep dive exploring our latest company, @irislabsinc, on our Substack, The Labs Report. Now, in a companion podcast, Avak Kahvejian sits down with iris labs’ CEO Armen Mkrtchyan for the story behind the data.
Full conversation here:
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"Why would we expect reasonable people doing reasonable things to create extraordinary outcomes?"
In a recent conversation with Secretary @HillaryClinton at the 2026 @ClintonGlobal Annual Meeting, Flagship Founder and CEO @NoubarAfeyan discussed taking a future-backwards approach to innovation — and why imagination is essential to reaching breakthroughs that cannot be achieved with reason alone. #UNGA81#
Watch the full conversation on YouTube now:
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AI is accelerating scientific discovery, from medicine to materials science. Where could the next breakthroughs emerge?
On October 13, @NoubarAfeyan, Co-Founder & Chairman of Moderna and Founder & CEO of @FlagshipPioneer, joins the #BloombergNewEconomy# Forum in New Delhi.
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.@irislabsinc has developed a robust parallel safety agent that operates alongside iris chat, designed to ensure conversations are handled with care and respect. The system reviews conversation context, guiding responses as needed.
For routine messages, iris chat operates as usual. For sensitive or critical moments, the safety agent helps shape the response by drawing on context and long-term memory to provide more tailored support, including encouraging users to lean on people and resources in their lives. The diagram below shows this system in action.
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People increasingly turn to AI for support, but LLMs that default to affirmation can fall short of building psychological fitness. Addressing this challenge requires AI that can do more than simply respond convincingly.
Following today’s announcement of @irislabsinc, we dive deep into how the iris labs team has made advances across two particularly important areas of AI: self-learning and safety.
Read the full write up on The Labs Report:
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Today we unveiled @irislabsinc, to transform human wellbeing through AI.
The first product from iris labs iris chat™, an AI thought partner designed to help people build meaningful relationships, develop a stronger sense of self, and live with greater purpose and fulfillment.
iris chat™ is available through iMessage and RCS.
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Today, Flagship was awarded up to $47M by the @DeptofWar to advance next-gen medical countermeasures against evolving biological threats. Initial projects include #FlagshipFounded# @AprioriBio & @Prologue_Med.
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Throughout civilization, the greatest periods of economic and societal progress have come when humanity unlocked a new source of productive capacity.
Our new initiative, Pioneering Abundance, is pursuing the next great unlock. Read our latest perspective:
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“We try and find problems that no one else is going to solve, and then solve them.”
Head of @Flagship_PI Matt Davis on how PI applies Flagship's whitespace approach to AI by pursuing what no one else will.
Watch Matt’s full 3 Questions:
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