🚨🇺🇦🇷🇺 Ukraine has launched A MAJOR drone attack targeting Moscow, as well as other parts of Central and Southern Russia. Officials are calling today's attacks the "largest-scale" of this year. Reportedly, over 800 drones have been used, with approx. 600 of them aimed at Moscow. The regional governor is already calling it "one of the most massive drone attacks in recent memory". Zelensky is giving Putin all he's got... Source: BBC, @sentdefender / Writer: Michael

I'm a cardiologist. For 25 years I've been trained to be brilliant at the worst moment of your life. The 3am cath lab. The stent threaded into a closing artery. The bypass. The shock that restarts a heart that had already quit. I've stood in those rooms more times than I can count, and I will never stop being in awe of what we can do there. But I need to tell you the quiet secret of my entire field: By the time you meet me in that room, the disease has already won most of the war. We are firefighters who show up after the house is halfway gone. We've built the most sophisticated rescue system in the history of medicine — and aimed almost none of it at stopping the fire from starting. 800,000 Americans still have a heart attack every year. A staggering share of them were preventable — not weeks earlier, but years earlier. We just had no way to see it coming. That is now changing, and the shift is so profound that ACC President @Drroxmehran and @EricTopol just laid it out as a once-in-a-generation turning point for medicine — a call to move cardiology from reacting to disease to predicting and preventing it before it ever declares itself. Here is what almost no one outside my field understands yet. Point by point. We've been staring at the wrong thing for decades. Old cardiology was obsessed with the narrowing — how clogged is the pipe on the angiogram. But here's the twist that still surprises even doctors: most heart attacks don't come from the tight, obvious blockage. They come from softer, "invisible" plaque that isn't blocking much of anything — until the day it ruptures without warning. We were reading the visible enemy and missing the one that actually kills. The real villains are inflamed, unstable plaque and the fire smoldering in the artery wall. We can now see that hidden fire. AI-powered CT scans of the heart can detect the dangerous features older imaging missed — the composition of a plaque, and the inflammation glowing in the fat around the vessel, years before anything ruptures. We are no longer guessing which plaque is a ticking clock. We're starting to read the clock directly. Your DNA can flag the danger before you have a single symptom. Polygenic risk scores add up thousands of tiny genetic variants into one number. They can identify people carrying 2 to 7 times the lifetime risk — people with normal cholesterol, no family history, no warning signs at all. A young, "healthy" 30-year-old could be walking around with a hidden inheritance we can finally catch and act on decades early. A photograph of your eye can predict your heart. This is the one that stops people cold. Deep-learning models can look at an ordinary retinal photo — the kind snapped at the optometrist — and estimate your biological age and your future heart-attack risk. The back of your eye is the only place in the entire body where we can see living blood vessels with the naked eye. It turns out they've been narrating your cardiovascular story the whole time, and we finally learned to read the language. And now the machines that tie it all together. Multimodal AI can fuse your genetics, your imaging, your medical record, and the data streaming off your watch into a single forecast of where your heart is headed — a living risk trajectory that updates in real time. Pair that with a new generation of drugs that crush the most dangerous cholesterol particles, cool inflammation, and protect the heart independent of weight — and primary prevention becomes something we've never had before: precise. Put all five together and something historic becomes possible: We can identify the person who is going to have a heart attack in 2045 — today. And we can rewrite that ending. Here's why this matters more than almost anything else in medicine. Of the great age-related killers — cancer, dementia, heart disease — heart disease is the most preventable. We already have the lifestyle levers. We already have medications that work. Statins alone cut the risk of a major cardiac event by roughly 20–25% for each substantial drop in LDL, and we've held that power for years. What we lacked was knowing exactly who to protect, and when to begin. Now we're being handed the map. Picture it: a routine checkup — or even an eye exam — quietly generating a risk profile that says this person needs us now, not in thirty years. That is not science fiction. Every single piece already exists and is maturing fast. I became a cardiologist to save lives. And I'm realizing the most powerful version of that was never the dramatic rescue at midnight. It's the heart attack that never happens. The room you never end up in. The ordinary Tuesday, twenty years from now, that you simply get to keep — never knowing how close you came to losing it. The tools are finally here. Our only job now is the courage to use them early — to stop waiting for the body to break before we're willing to care for it. The future of the heart isn't a better rescue. It's a life that never needed rescuing.

A TON OF THINGS HAPPENED IN THE STOCK MARKET TODAY. Here's a full recap: 1. Tesla $TSLA rose 5% today, marking its best day since early July. The move comes ahead of Tesla’s upcoming Cybercab Launch Event, where investors will be watching for concrete updates on robotaxi deployment, Cybercab production, autonomy progress, and whether Tesla can turn the vehicle from a concept into a real revenue-generating fleet. Tesla has already disclosed that Cybercab production has started, with public-road engineering tests and employee rides beginning at Giga Texas. The key question is whether the event delivers actual deployment details rather than another demo, including timing, fleet size, city expansion, and cost-per-mile economics. 2. Treasury Secretary Bessent today at the G20 summit said he believes the Japanese government and Bank of Japan will take actions that lead to a stronger yen. On the Fed, he said he would not speculate on what policymakers may or may not do, but added that traditionally “you don’t raise into a supply shock.” On bonds, Bessent said he and Warsh are “on the same page,” while noting he does not believe he can change the market’s equilibrium price. He also said Trump believes Iran is not ready to make a deal yet, and that Operation Outcast is aimed at creating conditions that bring Iran back to the table. 3. Anthropic has reportedly signed a $35B cloud deal with Lambda, an Nvidia-backed cloud provider, according to WSJ. The twist: Nvidia $NVDA is effectively the landlord. The data center is being built by Hut 8 in Nueces County, Texas, and Nvidia signed its own agreement with Hut 8 a few weeks ago to lock down the capacity. Lambda will use that space to run chips it bought from Nvidia, which is also one of its investors. The deal highlights how Nvidia is extending its role beyond selling GPUs and deeper into the AI infrastructure stack with financing, capacity access, cloud partners, and the physical data center footprint behind frontier AI demand. 4. The FTC and 22 states are reportedly preparing to sue Amazon $AMZN over alleged secret ad price hikes. The FTC is expected to claim Amazon manipulated its ad auctions by inserting its own “soft reserve” bid above the runner-up bid, effectively raising the minimum price advertisers had to pay. The practice allegedly began in 2018 and generated tens of billions of dollars over 7 years. In recent years, Amazon allegedly used the mechanism to raise minimum bids 70%–80% of the time, with the FTC claiming it increased pay-per-click costs by as much as 50% on major shopping days. Amazon generated $68B in advertising revenue in 2025, and this would mark the FTC’s third major case against the company after its Prime case and ongoing monopoly lawsuit. 5. Retail investors bought roughly $250M of Nvidia $NVDA shares on Wednesday, their 3rd-largest daily purchase since mid-May. That extended the retail buying streak to 15 consecutive trading sessions, with investors purchasing more than $2.5B of Nvidia stock over that period. For context, the largest daily retail purchase came in late February at about $1.0B. Over the last 12 months, retail investors have bought roughly $30.0B of Nvidia shares, the most of any Magnificent 7 company. 6. The White House published details of the U.S.–Venezuela oil deal, saying Venezuela has granted North American Blue Energy Partners 100-year concessions for 17 oil fields. The fields reportedly contain roughly 65B barrels of proven oil reserves, while NABEP plans to invest up to $100B into Venezuelan oil infrastructure to rapidly increase production. As part of the deal, the U.S. government receives a 35% equity stake in NABEP’s parent company at “zero cost to taxpayers,” the right to purchase 20% of all current and future production at production cost, and the right of first refusal on the remaining 80%. The U.S. also gets veto power over board appointments, with a majority of NABEP’s board required to be U.S. citizens. Venezuela is expected to receive roughly $200B in royalties and tax payments over the first 25 years, while the White House is calling it the “biggest oil deal in world history.” 7. U.S. annual interest expense has climbed to a record 18.5% of federal government revenue, officially surpassing the prior record of 18.4% set in 1991. This share has more than quadrupled over the last 4 years as interest costs on public debt have surged. Annual interest expense now stands at a record $1.25T, more than 4x the level seen in 1991. Meanwhile, the 30-year Treasury yield is trading around 5.21%, just 13 bps below its highest level since 2007. For context, the 30-year yield was around 8.00% in 1991, highlighting how much larger the U.S. debt burden has become. 8. BofA reiterated its Buy rating on Meta $META with an $810 price target, highlighting the potential launch of Meta’s consumer AI agent Hatch in early September inside Instagram and WhatsApp. Hatch can reportedly browse websites and navigate user interfaces to complete autonomous tasks like purchases, restaurant bookings, form filling, and communications. Meta is also reportedly targeting an October launch for its new AI model, Watermelon, which has shown frontier-level performance on certain internal benchmarks, with Hatch expected to integrate Watermelon’s automation capabilities after launch. BofA sees a major long-term opportunity in consumer AI agents, with Meta’s global user base giving it a significant adoption advantage, but said success will depend on ease of use, real utility, ecosystem integration, user trust around automation and security, and subscription pricing that creates consumer value while earning a return on Meta’s compute investment. 9. The top 10 most active options today by contracts traded were $TSLA with 4.4M contracts, $NVDA with 3.3M contracts, $AAPL with 1.3M contracts, $AMZN with 1.0M contracts, $MU with 952K contracts, $META with 606K contracts, $SPCX with 561K contracts, $INTC with 470K contracts, $PCG with 460K contracts, and $GOOG with 453K contracts. 10. Trump said interest rates are “too high” and said he has “a lot of respect” for Fed’s Warsh, adding that Warsh will “do what he has to do.” On Iran, Trump said any strikes would be limited, while noting that a lot of oil is still coming out of the Strait of Hormuz. He said ships came through Hormuz last night with Navy assistance and that the U.S. is averaging about 30 ships per night out of the Strait. Trump also said Iran “doesn’t know who the leader is,” adding, “we’ll see what happens.” 11. Take-Two $TTWO fell 7% as GTA 6 leaks continued ahead of the November 19 release. Recent leaked footage has reportedly shown combat, vehicle theft, the return of the six-star wanted system, a biplane flight over Vice City, and a 4.5-minute Lucia story clip. The pressure reflects growing concern around how much of the game is being revealed before launch, even as GTA 6 remains one of the most anticipated releases in gaming history. 12. China’s CXMT has reportedly started small-scale production of HBM3E, the advanced memory used in AI processors including Nvidia’s H200 and Blackwell GPUs, according to The Information. Alibaba’s T-Head and Cambricon are already testing CXMT’s HBM with their AI chips and could begin using it in products as early as 2027, with CXMT planning to expand production next year. The development could ease a key bottleneck for China’s domestic AI-chip industry, which remains restricted from buying the most advanced foreign HBM. The caveat is that CXMT is still facing low yields and remains roughly 3–5 years behind the leading HBM players, while $SKHY SK Hynix, Samsung, and Micron $MU are already mass-producing HBM4 and sampling HBM4E. WALL STREET IS THE GREATEST SHOW ON EARTH.

#Aimer# 26th Single "A World Where the Sun Never Rises" is out now! Theme Songs for Anime Series "Demon Slayer: Kimetsu no Yaiba" New Comments from Aimer and Mr. Shiina Go. Please check it out! #DemonSlayer# #InfinityCastle#

【NEW】 #Aimer# "A World Where the Sun Never Rises" Music Video YouTube Premiere at around 7:45pm JST July 24! Right after the Music Video Watching Party of Theme Songs for Anime Series "Demon Slayer: Kimetsu no Yaiba" ▼See here for details by staff #DemonSlayer# #InfinityCastle# #AWorldWhereTheSunNeverRises#

【Annoucement】 #Aimer# New song "World Where the Sun Never Rises" is the theme song for "Demon Slayer: Kimetsu no Yaiba Infinity Castle"!! Song available for streaming & download at midnight on July 19 (Sat) everywhere🎧 Full Single will be released on the later date too💿 ▽For more information Stay tuned! by staff #DemonSlayer# #WorldWheretheSunNeverRises#

This is Aimer. I am singing theme song for "Demon Slayer: Kimetsu no Yaiba Infinity Castle". Following the Entertainment District Arc, I’m truly delighted and honored to be involved in this work once again—this time together with LiSA. "World Where the Sun Never Rises" I’d be happy if you’re looking forward to it. Aimer

【New Artwork】 ＃Aimer 26th Single "World Where the Sun Never Rises" New Artist Photo＆Cover Art✨ ▼Pre-order your CD here (Japan only) by staff #DemonSlayer# #WorldWheretheSunNeverRises#

[Information] Tomorrow 7/22 (Sat.) from 6:00 p.m. *19:00- Japan time Aimer will perform at "BILIBILI MACRO LINK 2023" at Mercedes-Benz Arena in Shanghai! Free live streaming worldwide on BILIBILI! Please check it out! ▼Streaming URL by staff #BML2023#