I'm excited to announce that we are accepting applications from around the world this summer. I can't wait to see the amazing talent you have. What are you waiting for? Apply now! @ChromosomeEG

Chromosomes 17 and 16 are now live on Minos, bringing the total number of chromosomes in the network to 7. Chr17 carries BRCA1 and TP53, while Chr16 contains key genes implicated in kidney disease and blood disorders.

Chromosome Universe New Year Countdown Show 2025 Behind-the-Scenes Vlog is Ready to Watch 📽️ Our Boss @layzhang pours his love and heartfelt devotion for the stage into every tiny detail. The whole vibe is brimming with the warm ritual of ringing in the new year as one 💜 🔗 #LAY# #LAYZHANG# #ZHANGYIXING# #张艺兴#

Chromosome Universe New Year Countdown Show 2025 Stage Highlights！ Follow Boss @LayZhang and tuck the cheers of joy into the new year, as we carry our passion and legacy forward for another brilliant journey! #LAY# #LayZhang#

Next target: Chromosome 22 Chromosome 22 is clinically important. Some mutations here are linked to higher cancer risk, while others can change how people respond to common medications. Every chromosome we add brings Minos closer to a true genome-wide intelligence layer.

🚨 Scientists Successfully Remove an Extra Chromosome 21 From Human Cells Scientists in Japan have demonstrated a remarkable new approach for dealing with the genetic cause of Down syndrome. Using the gene-editing tool CRISPR-Cas9, researchers were able to selectively remove an extra copy of chromosome 21 from human cells carrying trisomy 21. Most human cells contain two copies of chromosome 21. In Down syndrome, there are three. Unlike conditions caused by a single DNA mutation, trisomy 21 involves an entire extra chromosome, making it much more difficult to correct. The researchers designed CRISPR guides that could recognize genetic differences unique to one copy of chromosome 21. The system then repeatedly targeted that chromosome, eventually causing some cells to lose the extra copy. In induced pluripotent stem cells, the researchers were able to restore some cells from three copies of chromosome 21 to the usual two. Under certain experimental conditions, the chromosome-removal efficiency reached 37.5%. The changes were not limited to chromosome number. Cells that lost the extra chromosome also showed changes in gene activity, growth patterns and antioxidant activity, moving closer to the patterns seen in cells with two copies of chromosome 21. The researchers also demonstrated that the technique could work in fibroblasts and in cells that were not actively dividing, suggesting that the approach may not be limited to rapidly growing cells. This is significant because scientists are not simply correcting one faulty gene. They are exploring whether an entire unwanted chromosome can be selectively removed from a human cell. However, this remains laboratory research and is not a treatment for people with Down syndrome. Major challenges remain, including safely delivering CRISPR machinery to the right cells throughout the body, avoiding unintended genetic changes and determining which tissues could benefit from chromosome removal. For now, the study provides an important proof of principle: researchers have demonstrated a targeted method that can remove an extra chromosome 21 from human trisomy 21 cells and partially reverse some of the associated cellular changes. Source: Mie University; PNAS Nexus

Minos Network is leveling up. Chromosome 19 is now rolling out, ahead of schedule. We’re moving beyond chromosome-by-chromosome approach. The network is now evaluating multiple chromosomes in parallel, expanding into new ones while continuously refining those already mapped. A bigger, more ambitious leap toward continuous, genome-wide intelligence.

Lay Zhang’s “Sucker” full stage performance at the CHROMOSOME UNIVERSE NEW YEAR COUNTDOWN SHOW 2025 is here! In the intertwining of sound waves and dance steps, every second is an irreplaceable moment of breathtaking splendor. #LAY# #LayZhang#