ROCHE KIDNEY DRUG HITS PRIMARY ENDPOINT IN PHASE 3 Roche and $IONS reported positive interim Phase 3 results for sefaxersen in IgA nephropathy, with the drug delivering a statistically significant and clinically meaningful reduction in proteinuria at Week 37. Sefaxersen is a once-monthly, self-administered antisense therapy targeting complement factor B. The safety profile was consistent with prior studies, with no new safety signals. The 459-patient trial will continue through Week 105 to evaluate long-term kidney function. Roche licensed sefaxersen from Ionis, which remains eligible for regulatory and sales milestones plus tiered royalties on net sales. The readout gives Ionis a second positive Phase 3 result in roughly 24 hours, following its FUS-ALS update.

🏥 A rice-grain robot dissolves kidney stones. Canadian researchers steer it with magnets, no cuts. Big surgery, tiny robot. Sources: U of T, Sci Robotics #omgfacts# #KidneyStones# #Robotics#