Why your first 10 minutes of focus always feel bad: - Your attention runs on 90-minute ultradian cycles, awake and asleep - For the first 5-10 minutes of a cycle, the circuits and neuromodulators aren't tuned to the task yet - Deeper into the 90 minutes, your ability to focus and direct neuroplasticity is much greater - Make every learning bout at least one full 90-minute cycle - Expect the early phase to hurt. It won't feel like flow - The focus and motivation circuits learn to drop in faster with repetition @hubermanlab

BOSTON SCIENTIFIC $BSX Q3’26 EARNINGS HIGHLIGHTS 🔹 Net Sales: $5.1B (Est. $5.05B) 🟢 🔹 Adj. EPS: $0.73 (Est. $0.72) 🟢; -3% YoY 🔹 GAAP EPS: $0.40; -22% YoY FY26 Guide: 🔹 Adj. EPS: $3.16-$3.18 (Est. $3.23) 🔴 🔹 Reported Net Sales Growth: ~+4.25% 🔹 Organic Net Sales Growth: ~+3.75% Q4 Guide: 🔹 Adj. EPS: $0.77-$0.79 (Est. $0.84) 🔴 🔹 Reported Net Sales Growth: -3.0% to -1.0% 🔹 Organic Net Sales Growth: -3.0% to -1.0% Segment Net Revenue: 🔹 MedSurg: $1.7B; +0.6% YoY 🔹 Cardiovascular: $3.4B; +1.9% YoY 🔹 Endoscopy: $741M; -0.8% YoY 🔹 Urology: $661M; -3.2% YoY 🔹 Neuromodulation: $331M; +13.1% YoY Announcements: 🔹 StoneSmart Solutions: FDA 510(k) clearance for two technologies 🔹 SEISMIQ: FDA 510(k) clearance for expanded sizing 🔹 Renal Denervation: Category I CPT codes effective January 2028 Other Q3 Metrics: 🔹 Net Sales Growth: +1.5% reported; +1.5% organic Comments: 🔸 “particularly to the cybersecurity incident, working with urgency and resilience to restore operations and continue supporting customers and patients.” 🔸 “As we move forward, I remain confident in our long-term strategy, fueled by our dedicated talent, differentiated portfolio and strong pipeline of meaningful innovation.”

Dario Amodei’s recent thesis is more than a forecast; it is a blueprint for the Great Compression. As the traditional software lifecycle from requirements to deployment collapses into a seamless dialogue between human intent and machine execution, we are witnessing the Death of the Coder and the Birth of the Architect. Programming is being subsumed because code is the ultimate structured data, but Software Engineering is not dying; it is ascending into high-level orchestration. Beyond the technical shift, Amodei outlines five pillars of AI-driven human progress: 1. Biological Compression AI will condense a century of biomedical progress into a decade. By mastering complex biological systems, AI will move us beyond treating symptoms to curing cancer, infectious diseases, and aging—drastically extending the human lifespan. 2. Neuroscience & Mental Health By unlocking the brain’s "black box," AI will replace trial-and-error treatments with precise neuromodulation and pharmacology. This revolution aims to eradicate depression and Alzheimer’s while optimizing human cognition and emotional resilience. 3. Global Equity & Leapfrog Governance AI serves as the ultimate equalizer. By optimizing resource allocation and providing universal access to elite education and medicine, it enables developing nations to bypass industrial hurdles and achieve rapid, "leapfrog" development. 4. Post-Scarcity Economics In a world where labor is no longer a prerequisite for survival, we face a transition to a post-scarcity society. Economic value will shift from routine output to human-centric creativity, deep interpersonal connection, and complex problem-solving. 5. Democratic Resilience AI will act as a bulwark for the rule of law. By neutralizing misinformation and enhancing judicial transparency, AI can strengthen democratic institutions and provide a powerful systemic check against the rise of authoritarianism.