World Lung is in full swing, which means the press releases are coming fast (before the papers or the sessions). 🫁 Why do we care in GI? Because all the shiny things start in lung and eventually make their way over here. HARMONi-2 compared ivonescimab vs pembrolizumab in PD-L1+ advanced NSCLC. We already knew the PFS result was kind of wild (in a China-only study): 11.1 vs 5.8 months HR 0.51 Now OS: 🔥 30.8 vs 22.6 months 🔥 HR 0.73 PD-L1 ≥50%: HR 0.58 PD-L1 1–49%: HR 0.85 So now this PD-1 x VEGF bispecific has beaten pembrolizumab for both PFS and OS in a randomized phase III trial. Yes, China only. Yes, pembro monotherapy is not really the comparator most of us would want for PD-L1 1–49%. Still. An 8-month OS difference is quite a bit. GI oncologists should be paying attention because this is already cooking in the first line mCRC setting with HARMONi-GI3. mFOLFOX6 + ivonescimab vs mFOLFOX6 + bevacizumab Is this an end-run around patent protection laws and PD1/PDL1's run out of time? (yes) Does the strategy have synergystic benefit? Time will tell. @OncoAlert @TheGutOncLab @Onco_Nexus

🫁 “Lung cancer is treatable—especially when caught early,” says Dr. Richard Gillespie, thoracic surgeon at Providence St. Joseph Medical Center. Learn the signs, risks & treatments for non-small cell lung cancer—the most common form of lung cancer. 🔗

Pope Leo's lung cancer diagnosis and surgery affected how Catholics view his health and papacy, the Vatican's foreign minister said, an unusually frank assessment by one of the Church's most senior officials

After her lung surgery, we almost said no to Antarctica. I already knew what a second time meant. If it came back once, it was going to come back again. The first time she was diagnosed, I refused to believe that. We were going to be the family that beat it. We were wrong. We said yes anyway. She stood on the snow in an orange jacket with Asteroid on her chest. She made it to Antarctica. Most people never do. We were not collecting trips. We were collecting memories with her.