DLSS 5 has been unofficially patched to run on RTX 30-series GPUs, but performance is very poor.
Modders patched leaked DLSS 5 Neural Rendering files to work on older Ampere cards. It can run, but it is far too demanding.
An RTX 3080 in Deep Rock Galactic dropped from around 138 FPS to 4 FPS with DLSS 5, a 97% drop. Other RTX 30 cards have fallen to 1–6 FPS in some games.