LSDとシロシビンでは、脳への作用が異なるのか?
Nature Neuroscience
健常者7人にLSD(25–200 μg)を投与
・脳血流量が約19%増加
・内頸動脈血流量が約28%増加
・脳全体の機能的結合性は低下
別の25人のシロシビン投与群では機能的結合性が逆に増加
同じ5-HT2A受容体を主な標的とする精神展開剤でも、脳機能への影響は必ずしも同じではないのかもしれません。
Do LSD and psilocybin affect brain function differently?
A new Nature Neuroscience study examined 7 healthy volunteers receiving LSD (25–200 μg)
• ~19% increase in cerebral blood flow
• ~28% increase in internal carotid artery flow
• Decreased global functional connectivity
Global functional connectivity increased in a separate cohort of 25 participants receiving psilocybin.
Despite sharing 5-HT2A receptors as their primary target, these psychedelics may have distinct effects on brain function.