what is happening here: claude used existing open source tools and orchestrated them together to do a protein design campaign (with a big guide prompt!) this is a win for claude because doing this orchestration requires a lot of biological judgement and knowledge however, the tools are doing A LOT of the lifting here so it is just as important to give credit where it is due to the open source academic community. this is not just typing into claude "hey give me a binder to X" and have it spit out a protein sequence. this also means that the limitations of these tools need to be thought about, and in particular we know that all of these tools fall down when faced with targets that are outside of the range of their training data (so we can't really design binders against most targets with them) so... this is cool but you really need to think about it in context