Anthropic and OpenAI released cheaper models on the same day with Claude Opus 5.5 and GPT-6. Dave McClure of Practical Venture Capital, Jeff Clavier of Uncork Capital, and Jenny Fielding of Everywhere Ventures join Jason to debate what that means for open-weight models. They also get into why fintech and healthcare are suddenly on the VC sideline, whether Meta's Muse leaves any room for Instinct, why it's a buyer's market for secondaries, and why median seed valuations have more than tripled since 2017. @jason @davemcclure @jeff @jefielding 0:00 What seed rounds looked like then: Fitbit's $2M seed 3:15 Jenny's Techstars NYC years and the two-unicorn mug 7:51 All-In Summit: Trump calls Jensen Huang onstage. Staged or not? 8:56 P(doom) roundtable + Dave's AI sovereign wealth fund prediction 10:08 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at 13:35 The AI intel error that nearly triggered a US-China incident 17:44 "McClure's Law": a human with AI is the real risk 19:59 Odoo - The all-in-one business platform. Your first app is free! Get started today at 21:37 Stripe + OpenRouter: an anti-fraud play, not a routing play? 23:07 Seed valuations: median $8M (2017) to $28M today 23:58 Instinct: $2.5B to a reported $10B in weeks 29:49 Rippling - Thanks to our partners at Rippling! Head to and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 44:01 Opus 5.5 vs. GPT-6 Sol: the same-day price war 46:51 Gun to your head: open-weight models or frontier labs? 51:00 Secondaries: the top 30 names vs. everyone else 52:30 Why fintech and healthcare are unloved (and Jason's Robinhood bet) 🎥 Watch the full episode here 👇