Huberman Lab Clips(@HLPClips):Most melatonin doses are 10 to 20 times too high: - Optimal doses for sleep benefits are 0.1 to 0.3 mg - Pharmacy and online supplements run 1 mg to 20 mg - 10 to 20 times what your body releases - Dose escalation is a marketing arms race: more milligrams for the same price - These are supra physiological levels of a hormone that is androgen suppressive when high - Seasonally breeding animals injected with melatonin had gonads shrink from almond size to a grain of rice - Animal data only. No specific human study on this @sleepdiplomat on @hubermanlab

2026.10.30 22:01

Most melatonin doses are 10 to 20 times too high: - Optimal doses for sleep benefits are 0.1 to 0.3 mg - Pharmacy and online supplements run 1 mg to 20 mg - 10 to 20 times what your body releases - Dose escalation is a marketing arms race: more milligrams for the same price - These are supra physiological levels of a hormone that is androgen suppressive when high - Seasonally breeding animals injected with melatonin had gonads shrink from almond size to a grain of rice - Animal data only. No specific human study on this @sleepdiplomat on @hubermanlab