Protection didn't require the psychedelic effect.
When the authors swapped psilocybin for tabernanthalog, a non-hallucinogenic compound hitting the same receptors, the mice got similar protection against nerve loss and pain. (Heles et al., Science 2026)
USC assistant professor
@rust_ruslan screened psilocybin and related tryptamines for neuroprotection in stroke. See the preregistered study, the reviews, and Ruslan's updates all in the open.