Antonio Linares
@alc2022
100x investor, bio/acc. do your own research. Early $AMD, $TSLA, $PLTR, $SPOT, $HIMS, $DUOL, $IBRX, $NAUT.
가입 November 2020
410 팔로잉 중 163.7K 팬
And how do you measure this?
Reading the proteome at proteoform resolution.
Using $NAUT, because no one else can do that.
Tentative bottom line: ATP synthase dimer angles could become a powerful structural biomarker of mitochondrial health.
If cardiolipin composition influences ATP synthase geometry, and that geometry influences cristae architecture, measuring dimer angles could provide a readout of mitochondrial structural integrity that conventional protein-abundance measurements miss.
The 2025 study makes this particularly interesting: simulated healthy cardiolipin membranes produced ATP synthase dimer angles of approximately 73° versus 65° in Barth syndrome-like membranes.
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