alex peysakhovich(@alex_peys):inspired by the anthropic post, i made a protein font! how does it work? when you design by differentiating backward through a folding model like esm-fold2 you can ask that the distogram of the folded protein looks like something you want. a little bit of help from @ChatGPT and now we have a protein font (fable, of course, didn't want to help me). this was not fully automated, i had to dial in some details like the protein sizes etc, but jointly me and codex got it working. i put the whole pipeline on my github below so you can mess with it too. bring your own gpus, its kind of expensive.

2026.08.19 04:49

inspired by the anthropic post, i made a protein font! how does it work? when you design by differentiating backward through a folding model like esm-fold2 you can ask that the distogram of the folded protein looks like something you want. a little bit of help from @ChatGPT and now we have a protein font (fable, of course, didn't want to help me). this was not fully automated, i had to dial in some details like the protein sizes etc, but jointly me and codex got it working. i put the whole pipeline on my github below so you can mess with it too. bring your own gpus, its kind of expensive.