Chaitanya K. Joshi(@chaitjo):Sometimes in academia ppl will say stuff like chai, protenix, boltz, openfold, rf3, etc. are all AF3 'clones' with an undertone around novelty, etc. I think this is such a wrong way to look at it, these models are all foundations for real products now and also importantly the journey to developing them and (as we see now) exceeding AF3 builds knowledge and understanding in the teams behind the magic! Having worked on these types of models myself recently, I found myself nodding along to Joshua here - its all really hard fought wins and compounding ablations :)

2026.08.10 17:08

Sometimes in academia ppl will say stuff like chai, protenix, boltz, openfold, rf3, etc. are all AF3 'clones' with an undertone around novelty, etc. I think this is such a wrong way to look at it, these models are all foundations for real products now and also importantly the journey to developing them and (as we see now) exceeding AF3 builds knowledge and understanding in the teams behind the magic! Having worked on these types of models myself recently, I found myself nodding along to Joshua here - its all really hard fought wins and compounding ablations :)