Huberman Lab Clips(@HLPClips):Depression is a metabolic illness: A bankrupt body budget. So fatigued you can't move and so distressed you can't think your way out. Look at the symptoms and they are metabolic deficits. One hallmark is the loss of positive anticipation about the future. If you feel unpleasant you won't predict anything pleasant, and learning from prediction error is expensive, so even the things that could give you pleasure go unnoticed. @LFeldmanBarrett on @hubermanlab

Huberman Lab Clips

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Huberman Lab Clips@HLPClips

2026.10.18 19:04

Depression is a metabolic illness: A bankrupt body budget. So fatigued you can't move and so distressed you can't think your way out. Look at the symptoms and they are metabolic deficits. One hallmark is the loss of positive anticipation about the future. If you feel unpleasant you won't predict anything pleasant, and learning from prediction error is expensive, so even the things that could give you pleasure go unnoticed. @LFeldmanBarrett on @hubermanlab