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Protection didn't require the psychedelic effect. When the authors swapped psilocybin for tabernanthalog, a non-hallucinogenic compound hitting the same receptors, the mice got similar protection against nerve loss and pain. (Heles et al., Science 2026) USC assistant professor @rust_ruslan screened psilocybin and related tryptamines for neuroprotection in stroke. See the preregistered study, the reviews, and Ruslan's updates all in the open.
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Just two doses of psilocybin administered before chemotherapy completely prevented mice from developing neuropathy
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