Michael Pearce(@_MichaelPearce):PCA reveals beautiful geometry inside a protein language model. But does the model actually use it? I explored how protein folds—like this beta-propeller fold—are represented in ESMC-6B using the interpretability tools built into Silico, @GoodfireAI's research platform 🧵

Michael Pearce

@_MichaelPearce

Interpretability @ Goodfire | Physics | Evolution | Ecology

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Michael Pearce@_MichaelPearce

2026.07.23 16:46

PCA reveals beautiful geometry inside a protein language model. But does the model actually use it? I explored how protein folds—like this beta-propeller fold—are represented in ESMC-6B using the interpretability tools built into Silico, @GoodfireAI's research platform 🧵