Antonio Linares(@alc2022):And how do you measure this? Reading the proteome at proteoform resolution. Using $NAUT, because no one else can do that.

Antonio Linares@alc2022

2026.10.30 12:37

And how do you measure this? Reading the proteome at proteoform resolution. Using $NAUT, because no one else can do that.

Antonio Linares@alc2022

2026.10.30 12:29

Tentative bottom line: ATP synthase dimer angles could become a powerful structural biomarker of mitochondrial health. If cardiolipin composition influences ATP synthase geometry, and that geometry influences cristae architecture, measuring dimer angles could provide a readout of mitochondrial structural integrity that conventional protein-abundance measurements miss. The 2025 study makes this particularly interesting: simulated healthy cardiolipin membranes produced ATP synthase dimer angles of approximately 73° versus 65° in Barth syndrome-like membranes.