🚨 This may be the most consequential oncology study of 2026.
Yes, on par with daraxonrasib.
At #
ASCO26# we highlighted the 5-year KEYNOTE-942 data for the individualized mRNA cancer vaccine intismeran + pembrolizumab in resected high-risk melanoma.
And the numbers were 👀
RFS HR 0.51
5-year RFS: 68.8% vs 49.1%
DMFS HR 0.41
OS HR 0.47 (still immature)
Amazing data. But 157 patients. Phase IIb.
The big question: does it hold up in phase III?
Apparently, yes. 🔥
INTerpath-001 randomized 1,137 patients with resected stage IIB-IV melanoma to intismeran + pembrolizumab vs pembrolizumab alone.
At the prespecified interim analysis:
✅ RFS met
✅ DMFS met
✅ Statistically significant AND
✅ No new safety signals
We don’t have the HRs yet. So some restraint until we see the actual data (also this is a press release, so grain of salt)
But why is this such a big deal?
Because this isn’t really about melanoma.
🧬 Sequence YOUR tumor
🎯 Identify YOUR neoantigens
💉 Manufacture a vaccine specifically for YOUR cancer
🦠 Train YOUR immune system to recognize it
And now that approach has succeeded in a randomized phase III trial.
This is actually personalized.
And if this platform works across tumor types, the implications are enormous.
Daraxonrasib may change how we treat RAS-driven cancers.
INTerpath-001 may change how we think about cancer vaccines altogether.
2026 has been an amazing year for oncology advances. 🔥
@OncoAlert @Onco_Nexus @TheGutOncLab