A Nature study links gut microbial single nucleotide variants, not just species and metabolites, to health and exposures. It analyzed 12.8 million variants across 10,781 people and found 940 independent associations with 69 host factors.

A nationwide referendum on Donald Trump. Record campaign spending. The economic fallout of foreign conflict and surging data centers. Ahead of the midterm elections, Bloomberg reporters from across the country break down some of the marquee races that will decide the balance of power and test the limits of executive influence

A native PC port of the original LittleBigPlanet PS3 is being developed, and the early build is already playable. >Native x86-64 PC code >Native Vulkan graphics renderer >Higher resolutions >Higher FPS support is being developed >Smoother rendering through frame interpolation > Physics, cloth, skinning and audio rebuilt for PC >Story levels already playable from start to finish >DLC support planned >Visual bugs and flickering are still being fixed Planned GitHub release for people who own the game legally, No original game files will be distributed The developer also says Claude Opus 5.5 was used to help with development.