Intracellular changes to receptor conformation alter how agonists bind to and activate the #GPCR# ACKR3 from outside the cell—illuminating the connection between receptor conformation, agonist binding kinetics, and constitutive activity. @UCPH_health

In a recent study, scientists show that intracellular changes to receptor conformation alter how agonists bind to and activate a biologically important #GPCR# from outside the cell through an “inside out” mechanism. @UCPH_health

In a new study, scientists show that intracellular changes to receptor conformation alter how agonists bind to and activate a biologically important #GPCR# from outside the cell through an “inside out” mechanism. @UCPH_health #Biochemistry#

In this week’s Editors’ Choice, we highlight a study by Rhee and colleagues in @Nature, showing how antibodies linking a GPCR with the transferrin receptor lead to GPCR down-regulation. Read a summary:

This week’s new issue of #ScienceSignaling# has arrived! Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more.

What's next for PeptAI? - Q2 2026: First on-chain wet-lab attestation via @Molecule_sci Labs - Q3 2026: Autonomous iteration cycle proven, GLP-1R Gen 1 library, design-vs-nature bioRxiv preprint - Q4 2026: Pipeline scales beyond GPCRs - Q1 2027: Lead optimization at scale, pre-IND scoping - Q2 2027: First in vivo studies, multi-target portfolio in parallel Follow @peptai_ for live gate decisions, candidate updates, and wet-lab results.