Science Signaling
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Science Signaling offers researchers the most up-to-date resource for groundbreaking research and commentary in the dynamic field of cellular signaling.
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Scientists identify a mutant #STAT3# protein in a patient with hyper-IgE syndrome, which forms dimers with wild-type STAT3 that have impaired transcriptional activity. @JoeMackie6 @Tangye_Lab @GarvanInstitute
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A team elucidates how the modification of transfer RNAs accompanies behavioral habituation and synaptic plasticity in the model sea slug A. californica—revealing how neuronal #tRNAs# are reprogrammed during a learning paradigm. @clarkkd25 @TuftsUniversity
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The new issue of #ScienceSignaling# has arrived!
The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more.
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A new slate of #optogenetic# tools enables scientists to finely control G protein signaling in excitable cells—providing a flexible method that might also be used therapeutically for disorders that disrupt the excitability of cells. @ruhrunibochum
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How do inflammasomes drive CAPS?
A mass cytometry analysis decrypts how #NLRP3# mutations in patient neutrophils trigger the clustering of gasdermin D and E at the plasma membrane, leading to #pyroptosis# and the release of IL-1-beta. @UCSanDiego
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In a recent study, scientists show that intracellular changes to receptor conformation alter how agonists bind to and activate a biologically important #GPCR# from outside the cell through an “inside out” mechanism. @UCPH_health
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Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment. @Tsinghua_Uni
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By developing tools that enable light-dependent activation of ion channels by receptors in a range of different cell types, a team has provided researchers with the means to control #GProteinSignaling# in excitable cells. @ruhrunibochum
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The enzyme #PRMT5# in vascular endothelial cells supports synapse formation and circuits in the cerebellum by suppressing the factor ANGPTL4, shows new work that uncovers an epigenetic link between the cerebrovasculature and motor control. @Tsinghua_Uni
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Scientists uncover a surprising connection between the brain’s maze of blood vessels and fine motor control in the cerebellum, new tools provide scientists with an optogenetic means to control G protein signaling, and more this week in #ScienceSignaling#.
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New work involving mice and patient cells reveals the mechanisms behind how neutrophils drive a rare group of autoinflammatory disorders called CAPS—and uncovers a potential new therapeutic target. @SciSignal
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In a new study, scientists show that intracellular changes to receptor conformation alter how agonists bind to and activate a biologically important #GPCR# from outside the cell through an “inside out” mechanism. @UCPH_health #Biochemistry#
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A preclinical analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to #oxphos# curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. @MayoClinic
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Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. @BUMedicine @VannaZachariou
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In this week’s Editors’ Choice, we highlight a study by Rhee and colleagues in @Nature, showing how antibodies linking a GPCR with the transferrin receptor lead to GPCR down-regulation.
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New work involving mice and patient cells reveals the mechanisms behind how #neutrophils# drive a rare group of autoinflammatory disorders named CAPS—and uncovers a potential new therapeutic target. @UCSanDiego
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Intracellular changes to receptor conformation alter how agonists bind to and activate the #GPCR# ACKR3 from outside the cell—illuminating the connection between receptor conformation, agonist binding kinetics, and constitutive activity. @UCPH_health
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How do inflammasomes drive CAPS?
A mass cytometry analysis decrypts how #NLRP3# mutations in patient neutrophils trigger the clustering of gasdermin D and E at the plasma membrane, leading to #pyroptosis# and the release of IL-1-beta. @UCSanDiego
Show more
This week’s new issue of #ScienceSignaling# has arrived!
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more.
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Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. @BUMedicine @VannaZachariou
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