ANGERME "Come On, Ise (Oinaisa, Ise)" MV out now! 🎉 Filmed on location in Ise, Mie Prefecture Watch and show your support by hitting Hype! 🔥 ▶️ @angerme_upfront #ANGERME# #HelloProject# #Jpop# #IseJingu# #JapanTravel#

NTT lost fixed telephone lines in all 47 Japanese prefectures last year. Its competitors gained lines in 21 of them and still finished 84,573 lines down. Japan's Ministry of Internal Affairs and Communications published the table on Friday, covering the year to 31 March. NTT is the former state telephone monopoly, privatised in 1985 and renamed NTT, Inc. last July, and its two regional arms still own most of the local access lines in the country. The whole network lost 762,676 lines on the revised basis the ministry now publishes. NTT shed 678,103. Its rivals shed 84,573. Both sides shrank. Two prefectures now sit below half. Mie at 49.3 percent. Nara at 49.4. A year ago Japan's communications ministry named one, Nara at 49.9. Mie is the only prefecture that crossed this year. Its rivals added 4,932 lines while NTT lost 10,473, and both moves pushed the same way. In Nara the rivals lost 3,659 and the share fell regardless. The two prefectures below half arrived by opposite routes. Copper explains all of it. NTT holds what the ministry calls a near monopoly of the metal lines, 92.4 percent of them, and metal fell from 28.3 percent of every line in the country to 25.6 in a single year, so the shrinking of that one category pulls the national share down on its own without anyone switching supplier. Then the figure that turns it around. NTT East's share went up, from 75.4 percent to 75.6. Only NTT West fell. A national decline that reads like competition is one half of one company losing copper in the west. NTT plans to end metal telephone service around 2035 and move customers to fibre or mobile. A line that moves to mobile leaves this count entirely. Japanese law puts a threshold at exactly one half, and crossing it lets the minister designate a carrier for open access rules. Nara crossed a year ago. In March Japan's communications ministry approved NTT's tariff for all 47 prefectures with no carve out.

Jose Manuel Cazarez-Pulido, 33, native and citizen of Mexico, has been charged for illegally re-entering the U.S. after having been previously removed, U.S. Attorney Jerome Gorgon for @USAO_MIE announced yesterday. This illegal alien was driving a Chrysler Town and Country van when he ran a red light that smashed into a motorcycle carrying a female, age 71 and a male, age 64. The two victims were critically injured. The case is part of #OperationTakeBackAmerica# - a nationwide initiative that: •REPELS the invasion of illegal immigration •ELIMINATES cartels and transnational organizations •& PROTECTS our communities from perpetrators of violent crime. Read more:

🚨 Scientists Successfully Remove an Extra Chromosome 21 From Human Cells Scientists in Japan have demonstrated a remarkable new approach for dealing with the genetic cause of Down syndrome. Using the gene-editing tool CRISPR-Cas9, researchers were able to selectively remove an extra copy of chromosome 21 from human cells carrying trisomy 21. Most human cells contain two copies of chromosome 21. In Down syndrome, there are three. Unlike conditions caused by a single DNA mutation, trisomy 21 involves an entire extra chromosome, making it much more difficult to correct. The researchers designed CRISPR guides that could recognize genetic differences unique to one copy of chromosome 21. The system then repeatedly targeted that chromosome, eventually causing some cells to lose the extra copy. In induced pluripotent stem cells, the researchers were able to restore some cells from three copies of chromosome 21 to the usual two. Under certain experimental conditions, the chromosome-removal efficiency reached 37.5%. The changes were not limited to chromosome number. Cells that lost the extra chromosome also showed changes in gene activity, growth patterns and antioxidant activity, moving closer to the patterns seen in cells with two copies of chromosome 21. The researchers also demonstrated that the technique could work in fibroblasts and in cells that were not actively dividing, suggesting that the approach may not be limited to rapidly growing cells. This is significant because scientists are not simply correcting one faulty gene. They are exploring whether an entire unwanted chromosome can be selectively removed from a human cell. However, this remains laboratory research and is not a treatment for people with Down syndrome. Major challenges remain, including safely delivering CRISPR machinery to the right cells throughout the body, avoiding unintended genetic changes and determining which tissues could benefit from chromosome removal. For now, the study provides an important proof of principle: researchers have demonstrated a targeted method that can remove an extra chromosome 21 from human trisomy 21 cells and partially reverse some of the associated cellular changes. Source: Mie University; PNAS Nexus