imo the millennium problem list in biology should be a list of very specific datasets like ‘a catalog of epitope-resolved nm protein binders across the human proteoform in X environment’. hard because it requires knowing the full range of human ptms/isoforms and having some way to do scalable generation/testing of epitope-specific binders (computationally or otherwise). both very difficult but achievable also verifiable!

AEON FRAMEWORK ECOSYSTEM MAP A new agent stack is forming on @base. A growing ecosystem of agents, products, terminals, infra, apps, and experiments building on top of @aeonframework. From @bankrbot to @PancakeSwap, @Powerloom, @clerk, @prmrsamm and more — Aeon is quietly becoming one of the most interesting agent frameworks on Base. The agent economy needs: • memory • skills • workflows • execution • distribution Aeon is turning that into an ecosystem. 42 projects, and counting...