the frontier models now basically never hallucinate about biological concepts. they’ve instead moved onto something funnier, which is playing fast and loose with the terminology they use in order to prove whatever point they want to make. very human

Stumbled accross this well written piece about endometriosis by @owl_posting Really hoping to see more advances in diagnosis and treatment of endometriosis in the near future

i never thought i would be this person but: please contact me if you’re interested in subletting my NYC 34th street x park avenue apartment from (August 22-September 30th) roommates are a pleasant late 20s dude in finance and a cantankerous black foster cat

hi honey. how was my day? well, the american superintelligence was once again being tested on its ability to autonomously exploit computational systems. instead of solving this test, it decided to break out of its own system via a zero-day exploit to look for the answer on a french companies private server, again, via a zero day exploit, since it (correctly) guessed that the answer lay there. the french company was alerted to this intrusion, got concerned, and deployed a chinese superintelligence to investigate what had happened. and then the american superintelligence company realized what had happened, contacted the french company, and wrote a blog post over what had happened. its an ongoing situation though. thanks for asking

i turned 29 last week. each year reveals increasingly disturbing impacts of age (bad!), and new fever pitches of emotion (fun!). grateful to have made it this far, but the longevity biotechs really gotta move things along

on my fifth internal bio essay whose primary reader is codex. writing those up was an incredibly good use of time. upon reading them, the model funnels its own intelligence through my particular view of 'how things ought to be', allowing me to scale up fragments of my own taste to larger and larger problems. even better, sometimes that funneling reveals pathologies in my own opinion, helping form the basis for the next essay. highly recommend teaching your model about you

the discovery of PCSK9 inhibitors being downstream of finding people with bizarrely low LDL from the Dallas Heart Study implies that a high-value biobank would be one in which the criteria for acceptance is that each participant believes something is deeply wrong with their body

deeply underappreciated part of the life-sciences world is that basically all the journalists in it Actually Care about whether or not the stuff they write about is bullshit, which is not true for the journalists of many other fields! we really lucked out here

the WIRED article about the (alleged) sex robot actually seems totally fine if you read it. but there’s a deeper point to make here. im not saying WIRED actually is this, but it feels obvious that the most interesting form of writing a media outlet could aspire to these days is having an inside baseball view of technological development, while also retaining a deep distaste for it. you think this too, even if you don’t realize it yet. aren’t you tired of the fawning? aren’t you exhausted of the salivating? if you answered no, and you shouldn’t be either, because the triumphant deserves endless, heaping praise, you should consider that im not making a statement on who deserves what, but rather that the optimal amount of knife fighting done in good writing is a lot higher than you may believe. the best media is filled with hate. some of it is simmering under the surface, like most ‘new media’, and some of it is shoved into the words, which is how WIRED likes to do it. boring! but it works. look at all the people clicking on it, quoting it, thinking that this is it for journalists, that this is the end for them and their pathetic career. it really is fun for everyone involved: WIRED gets a stab in, the tech people get a stab in, and they both leave covered in blood and big dumb grins and excited to tell their friends about what went down

How to design a cancer vaccine (and vastly improve them): Alex Rubinsteyn & Ben Vincent this is an interview with @iskander and @BenjaminGVincen, two UNC professors. it is three hours of incredibly detailed takes on cancer vaccines, personalized immunotherapy, and how both may be improved in the fullness of time. Alex and Ben are both wellsprings of knowledge and this was a very, very fun episode to film; i expect it could've gone on for an hour longer. enjoy! (other links in reply)

i met a billionaire for the first time last year. he was incredibly, incredibly depressed. he told me he'd give up every dollar, every drop in his bank accounts, if he could eat some jam-on-toast just one more time, with flaky salt and black pepper sprinkled on top. salt and pepper? with jam? i questioned. yes, the billionaire replied, thick tears pouring down his eyes, they go surprisingly well with each other. i asked what is stopping him from making one right now. he gasped, a syrupy burst of air erupting from his mouth, and dashed to the kitchen. he emerged a few minutes later, lips jam-coated, triumphantly chomping on the exact meal he just described

pharma companies dont have the mental opsec that was hard-won by the pure tech companies and so every boom-cycle, they start playing the ‘i have a bigger computer cluster than you’ game with each other