owl(@owl_posting):imo the millennium problem list in biology should be a list of very specific datasets like ‘a catalog of epitope-resolved nm protein binders across the human proteoform in X environment’. hard because it requires knowing the full range of human ptms/isoforms and having some way to do scalable generation/testing of epitope-specific binders (computationally or otherwise). both very difficult but achievable also verifiable!

owl

@owl_posting

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owl@owl_posting

2026.09.20 16:25

imo the millennium problem list in biology should be a list of very specific datasets like ‘a catalog of epitope-resolved nm protein binders across the human proteoform in X environment’. hard because it requires knowing the full range of human ptms/isoforms and having some way to do scalable generation/testing of epitope-specific binders (computationally or otherwise). both very difficult but achievable also verifiable!

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