A SIRT6 gene therapy trial in senior beagles hit its primary endpoint, lowering biological age and offering a test bed for human medicine. #longevity# #geroscience# #SIRT6# #genetherapy# #biologicalage#

Aged beagle data hint at lower biological age and preliminary muscle changes with SIRT6c treatment, although key readouts remain ahead. #longevity# #geroscience# #biologicalage# #muscle# #SIRT6c#

Peripheral artery disease affects 200M+ people worldwide, and restoring blood flow isn’t enough to repair damaged muscle. @WesternU researcher @HaoYin20 raised $10k on ResearchHub to investigate why. Now published as a Stage 1 Registered Report in @RHubJournal, Hao's project will test whether Sirt6 loss in vessel-support cells triggers a “senescence secretome” that actively blocks muscle recovery after ischemia. If confirmed, it could point to new therapeutic targets for one of the world's most common vascular diseases. Track the project here:

Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss Figure 1 The neurocardiac basis for cardiovascular disease and cognitive loss.