Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals “Higher mAA was associated with health deterioration and unfavorable lifestyles… Together, these findings support the potential of plasma metabolomic profiling as a scalable, life span–wide approach for deriving clinically interpretable metabolomic aging metrics associated with health status, chronic disease risk, and mortality.“

Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss Figure 1 The neurocardiac basis for cardiovascular disease and cognitive loss.

A new study in npj #Aging# suggests that #platelets# 🩸 may change well before frailty becomes physically visible. Researchers analyzed blood from 50 older women in Chile and found that platelets from women scoring just 7 or more on the 50-point Frailty Trait Scale (FTS-5), far below the standard frailty cut-off of 25, already show a procoagulant profile: more phosphatidylserine exposure, higher intracellular calcium, and elevated platelet-derived extracellular vesicles. Plasma proteomics pointed the same way, with signs of thrombo-inflammatory activity and a possible consumptive coagulopathy. Markers like CRP and D-dimer only shifted closer to the 25-point threshold, which suggests platelets may be an early warning signal. The sample is small and the design cross-sectional, so causality remains open, but a platelet-based liquid biopsy could eventually help flag frailty-related cardiovascular risk before physical symptoms appear.

GLP-1 Shows Promise for Patients with Advanced Fatty Liver Disease Clinical trial of semaglutide drug is first to show improvement in liver scarring among patients with early cirrhosis 🔬Efficacy and safety of zalfermin co-administered with semaglutide in participants with fibrosis and cirrhosis due to metabolic dysfunction-associated steatohepatitis: a phase 2, dose-ranging, double-blind, randomised controlled trial

Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses 👉 “Greater exposure to ultra-processed food was associated with a higher risk of adverse health outcomes, especially cardiometabolic, common mental disorder, and mortality outcomes.”

Longevity medicine moves into academic health systems “The systems are betting that their research ties will set them apart from the hundreds of private U.S. longevity clinics.” @BeckersHR

Is Longevity Medicine Going Mainstream? 👨‍⚕️ As major health systems open their own programs, longevity medicine is gaining credibility and becoming more accessible.

From the Translational Longevity Summit Top: Yours truly @agingdoc1 with featured speakers and friends Reena Bhargava and @AnmolMD. Bottom: Alan Jakimo, Shelly Jordan and Greg Fahey with @BernardSiegel and @HealthspanAct. Science. Innovation. Advocacy. Healthspan. 🚀

Each December, Ignacio Garcia hosts about 100 founders, investors and scientists in Zermatt for the Trampoline Zermatt Summit. Mornings include deep dives on healthspan, with scientific counsel from Aubrey de Grey. Worth a look if you work in longevity.

🤔Communication about longevity on social media is shaped by much more than the science itself. Economic interests account for a large share of it, since many of the most visible voices sell supplements, testing, or clinic services, or are paid through sponsorships and affiliate links to promote them. Psychology also plays a part. Fear of aging and the wish for some control over it make audiences receptive to confident claims, and the platforms tend to reward confidence more readily than caution. There is also the problem of getting information from research to the public intact. Much of the underlying work is paywalled, preliminary, or done in animals, and the people summarizing it often lack the training or the incentive to mention those limits. Ideology and aspiration add a further layer. Some communities treat dramatic life extension as close at hand, others regard any intervention with suspicion, and a good deal of longevity content works by offering viewers an image of the healthier, more disciplined person they hope to become. For these reasons, readers and investors are well served by bringing a high level of scrutiny to this field, and that applies to the content here as well. This page gathers what is circulating about longevity so it can be seen in one place, and sharing a post does not mean I endorse the views in it. I’d encourage keeping that scrutiny up even when a claim comes from a source you have trusted before. Wishing you good health and many good years to enjoy it. Take good care of yourself, and of the people who make those years worth having. Here's to long, healthy lives and plenty of time to spend them with the ones we love. 💛👨‍⚕️

A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging "We interpret aging as a possible by-product of the realization of the organism’s developmental program."

If heart disease runs in your family, how much can you do to change your risk? Genetics play an important role in cardiovascular health, but risk develops over decades and is influenced by factors we can often identify and address. Blood pressure, metabolic health, insulin resistance, and atherogenic lipoproteins all contribute to the picture. In certain individuals, advanced markers such as apolipoprotein B (ApoB) can provide valuable information beyond conventional LDL cholesterol measurements. The opportunity lies in understanding these risks early and translating that knowledge into evidence-based prevention, including lifestyle interventions and medical treatment when appropriate. I was pleased to contribute my perspective to HEARTproof, a new docuseries from @ZonaHealth exploring cardiovascular health, prevention, and longevity. 🎬 The free online premiere begins November 2: What has your family history taught you about taking care of your heart? #HEARTproof# #HeartHealth# #CardiovascularPrevention# #LongevityMedicine# #PreventiveHealth#

For Two Sisters, a ‘Biological Age Test’ Became a Ledger of Their Past They thought it might explain why their health had diverged. Instead, it stirred up feelings that weren’t so easily quantified.