We are deeply saddened to hear of the passing of former Wizard Jason Collins following his battle with glioblastoma, and are sending our condolences to his family & loved ones.

Throughout their first two full days on-orbit, the crew took the first-ever X-ray in space, 130 years after the first X-ray was captured. The @framonauts did a brain mapping EEG experiment and contributed to a continuous glucose monitor study examining how fluid shifts in space affect the accuracy of glucose monitors for diabetics. Chun, Jannicke, Rabea, and Eric also transferred images for Fram2Ham, took conference calls in space, and were able to chat with their families thanks to @Starlink

Developing (adjective) | de·vel·op·ing |: another word for trash. 😂 @Rjeff24 and @channingfrye take a trip down memory lane on the first episode of #Bundled#. @uninterrupted x @geico 📺:

People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295. It pushed my growth hormone up by ~8x. That’s good. That’s what it was supposed to do. But, it also came with adverse effects: > increased my morning fasted blood sugar up 20% > increased stress hormone by 12% > tanked my REM sleep by 23% > made my pancreas work 53% harder and was still losing to rising blood glucose > increased my insulin resistance by 50% These were the most obvious side effects, and I only ran a very narrow panel for this experiment. So I’m sure there’s more. I stopped after two doses, without even reaching the intended target dose. For those of you new to peptides, your body sends instructions to itself using tiny chemical messengers called peptides. There are thousands of them. For example, GLP-1s are drugs that take an existing class of short-lived peptides and modify them to extend their activity duration, which turns them into drugs, following rigorous clinical testing. CJC-1295 is one of those peptide-drugs. It tells your brain to release more growth hormone. Growth hormone is your body's signal to build muscle, repair tissue, and recover. However, and like most grey market peptides, CJC-1295 did not succeed its clinical trial, and hence never became an “official” drug. There is a version called CJC-1295 with DAC. DAC is an attachment glued onto the peptide that makes it last for days in your body instead of hours. One shot, longer effect, just like GLP-1s. Why people use it: more growth hormone could mean better recovery, leaner body, faster healing. The experiment I completed. Two injections a week of CJC-1295 with DAC: > 1.2 mg > 1.8 mg 48 hours after the first injection I was nearly comatose. It felt like severe jet lag, the type you’d feel after traveling nine time zones. My sleep was wrecked and I felt continuously awful. My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued. Why we chose CJC-1295 with DAC. Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, mixed with another peptide called Ipamorelin. We went with CJC-1295 with DAC instead as it has the most controlled studies. CJC-1295 with DAC has 2 controlled trials in healthy adults. Ipamorelin alone has 1 controlled trial in healthy adults, plus 1 study that failed when they tried it on bowel surgery patients. The mix of the two has zero controlled trials. On Ipamorelin, it copies a chemical called ghrelin, the one that makes you hungry. On its own it gives you a quick burst of growth hormone that fades fast. It does not keep your longer acting growth signal (called IGF-1) up. Clinics mix Ipamorelin with CJC-1295 no-DAC because the two together are supposed to work better. But we don’t know if that’s accurate because we don’t have trial data. This is a problem with peptides. Almost none of them have been tested properly. We are flying blind. Most of what people use is based on what someone said online, what a clinic claims, or what a friend reports from their subjective feelings. Peptides have the potential to be great when well-studied.

Berkshire Hathaway underperformed the S&P 500 by more than 30-percentage points over the last year! Berkshire's only annual performance that was worse was in 1999 -- during the Internet mania. Today, though, Berkshire owns Apple and Google, unlike in 1999 when it didn't own any tech stocks. So, what else could explain the company's declining performance? More than a decade ago, researchers at AQR ran a series of regression studies across 30 years of Berkshire's public stock investments to discover which factors drove Buffett's outstanding investment results. They discovered -- to no one's surprise -- that Buffett buys ultra-high quality, large-cap, low-volatility stocks that are extremely cheap. But that's not all they discovered. They also disaggregated Buffett’s portfolio into two distinct sleeves and then ran the same the regression studies on each separately. The public sleeve is the portfolio of publicly traded stocks held inside Berkshire’s insurance subsidiaries — disclosed quarterly in SEC Form 13F filings. This is what most financial press coverage focuses on. The Coca-Cola, the American Express, the Apple, the Bank of America. Over the full sample it averaged about 35% of Berkshire’s total capital. The private sleeve is the portfolio of wholly-owned operating businesses — See’s Candies, Nebraska Furniture Mart, GEICO after the 1995 full acquisition, BNSF after 2010, Berkshire Hathaway Energy, Dairy Queen, NetJets, Precision Castparts, the whole roster of consolidated subsidiaries. Over the full sample the private portion grew from under 20% of Berkshire to more than 78% today. Berkshire was once an insurance company with an equity portfolio. Today it’s an insurance company owned by a conglomerate. And here's why that matters. The public sleeve — the portfolio of stocks Buffett bought fractionally and held — earned an average excess return of 12.0% per year at 16.2% volatility. Sharpe ratio: 0.74. The private sleeve — the portfolio of whole companies Buffett bought outright — earned an average excess return of 9.3% per year at 20.6% volatility. Sharpe ratio: 0.45. The publicly traded pieces of companies Buffett owned delivered materially better returns, especially when compared against the risk taken. The private sleeve’s Sharpe ratio of 0.45 is, remarkably, lower (worse) than the broad market’s 0.49 over the same period. In other words, when Buffett bought pieces of great public companies, he outperformed. When Buffett bought whole private companies, he did not. The private sleeve’s drag on Berkshire’s overall performance is meaningful. That drag was smaller in the early years, when the private portfolio was only 20% of the business. As the private sleeve has grown to 78% of Berkshire’s capital, the drag has grown proportionally. The declining Sharpe ratio of Berkshire over time — which every long-term shareholder has felt, even if they could not name it — comes primarily from the growing share of capital trapped inside whole-company acquisitions that underperform the public-market alternatives Buffett could have bought instead. Learn more about Warren's Mistakes and how to learn these lessons to improve your own investing in my new book.

As a gynecologist, let me explain; This is what female ejaculation (squirting) is like 💧🌊✨ Female ejaculation, or squirting, is a real biological phenomenon, though it's surrounded by myths. It's not entirely urine, but the expulsion of a clear fluid during intense sexual arousal. Sometimes it's completely mistaken for urine. This event is directly related to the deep stimulation of the G-spot (an extremely sensitive area on the anterior vaginal wall) and the degree of activation of the parurethral glands of Skene, the functional counterpart of the male prostate. "Squirting" comes from a specific gland: Female Prostates: Skene's glands are a series of glands and ducts located around the female urethra, just behind the pubic bone. They are rich in a specific type of prostatic antigen (PSA). PSA is a protein also present in male ejaculation. Deep Stimulation: When the G-spot (a highly vascularized area in the urethro-vaginal space) is stimulated with sufficient intensity and pressure, these glands become more active. Urethral Expulsion: Skene's glands secrete a clear fluid that accumulates in small sacs and is expelled through the urethra in a jet-like manner during orgasm due to the contraction of the pelvic floor muscles. Why is it so different from other types of orgasm? Clear and Odorless Fluid: The fluid released from Skene's glands is clear and has a different chemical composition than urine. It contains glucose, urea, creatinine, and PSA, but in very different concentrations than urine. Sometimes, this fluid may be accompanied by varying amounts of urine. Muscle Contractions: The expulsion of the fluid is accompanied by strong contractions of the pelvic floor muscles, acting as a "pump" to release the accumulated fluid. Not everyone experiences squirting. The intensity of stimulation, individual anatomy, and psychological relaxation are key factors. MEDICAL NOTICE 🩺 It is important to know that squirting is a normal and healthy sexual response and should not be confused with urinary incontinence. Unveiling this phenomenon could be important so that women can explore their sexuality without shame.