Medicine is a compute problem. This model was able to predict your next health event. Trained on 300M patients and 16B health encounters. We overestimate the mystery of our bodies and are more predictable than we want to believe. Cool seeing that illusion chipped away.

A biological attack is planned for Saturday 600 million pounds of sugar laced with synthetic chemicals will enter the bodies of our children. Wreaking metabolic havoc, injuring vascular architecture, acidifying oral lining, releasing bacterial toxins, and blunting neural reward pathways. Instructing that gluttonous consumption of poison is celebratory.

I have an AI agent that logs every negative comment someone makes about me online. It then creates a profile of the person, maps all of their social connections, and finds all their emails. Tomorrow morning, my AI agent will sent out an email blast to everyone's extended social network, detailing the horrible things they've said about me.

International travel is biological wreckage. It's not my intent to rain on your parade or suggest you not travel. I learned first hand from measuring my biomarkers traveling to China, India and Australia. Sharing to be useful in your life decision making.

I used to learn a new vocabulary word every day. Then I experienced the social friction of using less understood words and reverted to the mean, a lower dimensional, opaque space. It would be exciting if we endeavored to expand and easter egg vocabulary.

The global era of Don't Die begins in 2030. New age reversal therapies will emerge and automation will run our lives, removing the biggest blockers of health: discipline and effort. Death acceptance will vanish as fast as body positivity did with GLP-1s.

I reviewed Tobi’s biomarker’s from the car race yesterday. His heart rate, respiration, nervous system, focus, brain state, and more. It’s insane. I have some observations below. First, you need to get into the right headspace to understand the insanity. Imagine this… > you're breathing at an 8 min/mile (5 min/km) pace > in a 110°F (43°C) heat chamber > heart rate of 145 bpm, peaking at 171 bpm > intermittently body checked 700 lbs (320 kg) of force > your core body temp near 102°F (39°C), a high fever > claustrophobically strapped in a six point harness > helmeted head weighs 65 lbs (30 kg) under g load > no evaporative cooling > you’ve lost 4.6% of your body mass through sweat > you can’t move > vision narrowing from thermal strain and dehydration Now, in these circumstances, your job is to… > drive a tightrope at 180 mph (290 km/h) > overtaking/defending against ahead, beside, behind > staying within millimeters of tolerance > lose concentration for a tenth of a sec, in trouble Do this for 2.5 hours straight. A few additional things I find interesting from looking at the data: 1. It’s crazy to me his body can be in such a heightened state while completely stationary. Sitting down, he produced a cardiac load equal to high intensity physical exertion. 2. Thirty minutes before the race, Tobi’s body was already racing. His heart rate elevated to 136 bpm, more than 2x his baseline. 3. In qualifying, the higher his heart rate, the faster his lap. Arousal and performance moved in sync, including his personal best lap. 4. He lost 4.6% of his body mass in sweat. This is severe dehydration. At 2% dehydration your reaction time measurably decreases. He surpassed this in the first hour. 5. His nervous system was switched entirely to fight. There was no chill, anywhere. 6. His incredibly high breathing rate was driven by extreme sympathetic stress and rising core temperature, averaging 41 breaths a minute on his flying laps, moving 93 liters of air a minute. 7. His peak respiratory rate was 59. This is an all out sprint! 8. The only life experience I can map onto Tobi’s experience was doing 27 mg of 5-MeO-DMT, the world’s most powerful psychedelic. It was all consuming, taking me to the cliff of my physical and mental capacity for 45 minutes. Otherwise, it is very hard for me to imagine being able to excel in these extreme conditions for 2.5 hours. | I now understand a little more what Tobi was telling me about the flow state he drops into. Under such extreme physiological conditions, the brain ruthlessly narrows focus. His brain downregulates the self-monitoring prefrontal regions (the self narration). The spike in norepinephrine dilates time, creating the perception of time slowing down. MRIs on professional drivers show they use roughly one brain region for tasks where novices light up fifteen. A novice would be crushed in these circumstances in less than 10 minutes. I’m impressed. It’s very hard and nearly impossible to actually understand what it’s like to go through something like this. Tobi and @dhh (Tobi’s teammate) were both my first customers at Braintree and gave my startup life when it wasn’t clear if we had a future. They generously encouraged other startups in the Ruby on Rails community to use us. DHH’s co-founder @jasonfried did as well. They’ve been great friends to me. As to Tobi’s performance in the race, he did exceptionally well: > closed within +0.51% of the fastest Bronze driver, putting him neck and neck with the top ranked amateur drivers in North America > got his fastest lap of the race on Lap 88 (1:15.359), over two hours in and with peak dehydration and thermal strain, showing incredible tenacity > finished just +2.60% off absolute class best, competing against world class professionals There were 150 drivers competing in this race. Respect to all of you. I have a whole new appreciation for the sport.

Car racing is cognitive enhancement: > 12 hrs on a driving video game, and 60-85 yr olds were cognitively overtaking 20 yr olds > race car drivers do in one brain region what a novice does in 15 > six months later, the seniors kept the gains with zero practice

He just got off the track. Now we’re reviewing Tobi’s performance via biomarkers. This is for qualifiers. We’re looking at: + the car stats + his micro decisions + his blood biomarkers Race day is tomorrow.

I’m watching three friends lose 11 lbs of body weight in a race car tomorrow + Tobias Lutke (founder shopify) + DHH (creator ruby on rails) + Mathias Beche (le mans podium) Race car driving is insane… + 122°F cockpit + heart rate 170 + 2.5 hours straight + 10 hr race + up to 4.2 g force (wild) + multi-layer fireproof suit + sweat barely evaporate + 600-900 calories per hour The race is a 10-hour endurance track in atlanta. It’s called Motul Petit Le Mans. Tomorrow is the season finale, where 54 cars across multiple classes run roughly 400 laps of the 2.54-mile road. The race doesn’t end till 10 pm. They’ll be driving an LMP2: + 603 horsepower + 2,050 pounds + 9,000 rpm I’ve personally experienced some of the above things: > core body temp of 102°F > 3 g force in my airplane > non evaporative clothing > stomping 200 lbs > severe dehydration But never all at once… inside a race car for 2.5 hours straight, competing for tenths of a second, and in a high risk environment. I’m struggling to get my head around it. Last week, Tobi and I were at a conference catching up. He and I have been friends for 15 years. Tobi and DHH were my first customers at my payments startup Braintree. I’ll forever be grateful to them and DHH’s co-founder @jasonfried for giving my company life. Tobi approaches racing as I do my body. Data, method and analysis. A closed loop game of continuous improvement. Off the track, Tobi: + founder and ceo of Shopify + 6 million+ merchants + $195 billion market cap + 20 yrs building Off the track, DHH: + created Ruby on Rails + co-founder 37signals + 20 yrs building + profitable, no outside capital + 24 Hours of Le Mans class winner On the track, Mathias Beche: + 24 Hours of Le Mans podium finisher + European Le Mans Series LMP2 + FIA Endurance Championship winner + 15+ career prototype victories What a team of bad asses. I’m excited to be in the pit on tomorrow and watch all of this go down.

To be a strong country, citizens can’t be burdened by the state. Proud that my friend @jgebbia and team have done that for the U.S. Making painful and annoying citizen-related things easy.

humans hold a drink in their hand at social functions to calm social vigilance and mirror cultural patterning. the physical grip stabilizes against fidgeting and a sip grants a 3 second safe zone for responding and turn taking. ingestion is an evolutionary cue of safety.

Cool that an AI agent found the new CRISPR like system by reading the raw genetic code like plain text. It was a lucky find because the agents missed it on ten consecutive runs when in bio software. I guess our bodies needs to be in plain text and then we won't die.