If Hantavirus mutated into a global threat, it would unleash AI + biotech unlike anything we've ever seen. > genome sequenced and public in 4 hours > AlphaFold maps every protein target > AI screens 10,000 drugs in 24 hrs > 50 vaccine candidates designed simultaneously > AI designed antibodies in days > risk of death computed instantly > decentralized trials launch globally > enroll from home > 20 countries manufacturing at once > first doses in three weeks > real-time dose characterization > your genome + biomarkers determine your protocol > variant map updates every hour No one would wait for governments.

Scientists made fish trip balls with magic mushrooms. It helped the fish with anger management. The research was done on a mangrove rivulus, a small Caribbean fish that is famously highly aggressive and territorial. If a stranger fish gets put into a mangrove rivulus's tank, it gets mad and will dart and lunge to chase the new fish out. Psilocybin (the psychoactive compound in magic mushrooms) was added which the fish absorbed through the gills and skin. It chilled the fish out. > moved around 80-100 fewer seconds during the trial > 2 to 3 fewer angry lunges at the stranger fish Not all aggression was turned off, but the explosive attacks dropped. A lot of studies show mushrooms help with sadness and fear in mice and humans. Aggression has been understudied in modern psychedelic research, especially in social settings. Why it matters. A fish brain is old in evolutionary terms. Fish and mammals split off from each other something like 400 million years ago. If psilocybin can dial down aggression in a fish brain, the wiring for aggression has probably been conserved across that distance. The same brake could exist in humans.

Last year I nearly shut down Blueprint. My reasoning was that in the grand game of existence, getting our societal goals right is the only thing that matters. In the long arc of time, it wouldn't matter if I built a longevity company. I wanted to invest all of my energy into Don't Die. Maybe I'm naive, however it seems obvious to me that when your species is giving birth to superintelligence, your sole concern becomes survival. Not because you're scared or fear what may come, but because you realize that superintelligence is big. Bigger than any of us can imagine and happening faster than our intuitions allow us to model. This is a hard concept for Homo sapiens to understand because we are not good at understanding our limitations of knowing. In the void of not knowing, the one thing that we each know to be true is that none of us want to die right now. When tomorrow arrives, that will be true about the next day too. Don't Die is not about immortality. It's about the most basic observation of intelligent life, we want one more breath. Just as Homo erectus, a million years ago, with an axe in their hand, was unable to articulate our modern world, we are once again Homo erectus relative to AI. We may experience a million years of relative progress in the next 10, 20 or 50 years. Given this, Kate and I have cycled through this problem hundreds of times over the past few years. How can we get the world aligned around Don't Die? Committed to the idea that in spite of our many differences, we share a planet and a common interest in tomorrow. Basically, how can we make existence profitable and die unprofitable. We saw the problem as two-fold. One practical and one spiritual. Practically, we need things to work in the world: clean water, transportation, energy, security, stable institutions, communications and health care. Spiritually, we need purpose, existential explanations, and hope. We also need progress and adventure: solve aging, abundant AI, creative joy and expression and things to build. We decided to build on both fronts. Blueprint would be the practical, a company aligned to Don't Die. A group of humans that labor together to help other humans thrive as their sole objective. To hold ourselves to a standard of making existence profitable and die unprofitable, for ourselves. To never let profit corrupt this goal. Sounds simple until you take stock of how many companies make their living on making humans die. Sometimes this is done openly and other times it's hidden in a mesh of poorly aligned incentives that are invisible. This is not an esoteric philosophical argument, death is measurable in a biological system. You can get clever and find arguments ("does this mean we shouldn't have children?") but we know death and life when we see it. On the spiritual side, we think that 2027-28 is the breakout time for Don't Die. Maybe we're off by a year or two, but we think it's soon. We believe that AI will create several societal shocks, none of which we will predict accurately, but will leave the world feeling unmoored. Hopefully it won't be catastrophic, but will be a cold water dunk we need to awaken us to the realization that no one really wants to die right now and that our current societal systems that profits from death are ill suited for this moment. That in our most sober moments, when at funerals, or after a near-death experience, we see clearly, even if for a few minutes. Above all, we care about life more than anything else. All else fades away in those moments. We see with crystal clarity that all the other stuff that had us entranced wasn't that important after all. I write this for two reasons. First, to invite you to build Don't Die in the practical world. Capitalism (profit and loss) is a good system that has done society well. In whatever you're building, align your and your organization's efforts with a loyalty to acting in people's best long term interests. Don't do things that cause other people to die, commit self harm, or create societal harm. This doesn't mean being paternalistic, it means using your best judgement about how you'd want someone else to treat you if the roles were reversed. Second, to ready yourself for the new philosophy that will be arriving shortly. One that prioritizes our shared existence and vitality above all other goals. Don’t Die is the foundation. Immortalism is what we’re going to build. Again, not for selfish reasons, but because we understand that we are warriors and caretakers of intelligent life in this part of the galaxy and we take on this responsibility with honor and nobility.

This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most powerful drug. 1. Be in your bed for 8 hours 2. Same bedtime every night, any time before midnight 3. Don’t eat right before bed 4. Calm foods for dinner 5. No screens 1 hour before bed 6. Avoid added sugar (be aware it’s in everything) 7. Avoid all things in an American convenience store 8. Avoid fried foods 9. Shoes off at the door 10. Eat whole foods, particularly veggies fruits nuts legumes berries 11. Walk a little after meals or air squats 12. Get your heart rate high routinely 13. Lift heavy things 14. Stretch daily 15. Water pik, floss, brush, tongue scrape, morning and night 16. Make an effort to drink water 17. Get sunlight when you wake up (UV is low) 18. Protect skin in midday sun 19. Stand up straight 20. See at least one friend once a week 21. Avoid plastic where you can (in all things) 22. Circulate air in rooms 23. When stressed, breathe, learn to calm your body 24. Go to the dentist 25. Avoid sitting for long times 26. Protect your hearing, the world is too loud 27. Alcohol is bad for you 28. Finish coffee before noon 29. Avoid bright lights after sunset 30. If obese, look into a GLP 31. Sleep in a cold room 32. Texting while driving is dangerous 33. Turn off all notifications 34. Limit social media use 35. Don’t smoke anything 36. If you struggle to sleep, read a physical book before bed 37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music 38. The body is a clock and loves routine. Have a daily morning and evening schedule. 39. Avoid long distance travel where you can 40. Baby steps first: incorporate new things slowly 41. Do less… most things don’t work. Bonus points if you get your blood checked. Start here, it will change your life.

His claim is correct. We have a fertility crisis. > 62% sperm count drop globally 1973 - 2018 > 23% drop in just 16 years > rate of decline accelerating > dropping 2.64% per year since 2000 I explain below how to improve yours. I've been working on improving my fertility markers for the past two years. They are elite for a early 20 something (I'm 48). Total motile count: 411 million Motility: 64% Morphology: 12% Concentration: 212 million Count: 642 million To put these numbers into perspective: the WHO considers a motile count above 42 million as normal, mine is 411 million, nearly 10x. And a normal concentration is 16 million (mL), mine is 212 million (mL). These personal-best fertility markers coincided with my first-in-human test result showing zero microplastics in my semen. Studies have shown 100% of men have microplastics in their semen. Microplastics hurt sperm. Human studies show the impact of various types of plastic, associated chemicals, and other toxins on male fertility: + 60% fewer normal shaped sperm (from PFAS) + 5x higher odds of low sperm count (from PTFE) + 10% lower sperm concentration (from PTFE) + 15% lower swimming ability (from PTFE) + 41% lower swimming ability (from PET) + 12% lower sperm swimming ability (from BPA) + 3x higher odds of low sperm count (from Phthalates) + 2x higher odds of poor swimming (from Phthalates) How to improve your fertility: > 7 to 9 hours of sleep, consistent bed and wake times > exercise: cardio fitness, strength, and muscle > reducing body fat and build lean mass > avoid alcohol, tobacco, and cannabis; each independently reduces sperm concentration, motility, and morphology, with cannabis also affecting sperm methylation. > cut junk food, added sugars, and excessive saturated fats > eat an anti-inflammatory, anti-oxidant diet (Mediterranean and green-Mediterranean): polyphenols, fiber, olive oil and other MUFAs, omega-3s (algal, fish, walnuts), plant protein, fresh veggies. > get full micronutrient coverage: zinc, selenium, folate, vitamins C, E, and D (blueprint solves this). > manage stress and cortisol load; chronic stress lowers testosterone and impairs spermatogenesis. Things I'm doing: 1. Sauna (dry). My toxin blood panel confirms sauna clears plastic related chemicals: BPA, phthalates, PFAS, flame retardants, pesticides. The plastic particles themselves are too big to sweat out directly. Heat may activate other clearance routes: bile flow through the liver, the cell's internal cleanup system, and the gut barrier. Humans have almost no enzymes that can break plastic apart, so the body has to physically push it out. 2. Reverse osmosis water filter. Drinking water is likely a major source of microplastic getting into your body. A reverse osmosis filter pushes water through a very tight membrane and strains the particles out. I filter everything I drink. 3. Trying to rid my environment of the big plastic items: cutting boards, cups, plates, food storage containers, non-stick pans, cling wrap, tea bags, water bottles, kitchen utensils, kettles, and synthetic clothing. Note, as hard as I try, I'm always finding new plastic things in my life. This can be all-consuming thing so try to just knock out the big ones. The studies: > meta-analysis with total 42,935 men; significant decline in both sperm concentration and total sperm count among men from Western countries, with total sperm count by about 59%, between 1973 and 2011. > A follow-up global meta-analysis, expanded the dataset to 223 studies and 57,168 men found the drop in sperm count was not only a Western phenomenon > total sperm count dropped by 62% globally between 1973 and 2018, including in men from South America and Asia. The rate of decline has also accelerated since 2000, reaching approximately 2.64% per year. > CDC data also showed US fertility rates peaking at the replacement level of 2.12 births per woman in 2007, then taking a sharp downward turn by 23% down to 1.62 in 2023.

Kate and I spent the weekend forest bathing. A cabin in deep woods, a river feeding the ocean, tides marking the day. We hiked, watched, listened, and smelled. We let the quiet settle. By Sunday morning, my resting heart rate dropped by 10%. The storms of the modern world were shedding. We were eating lunch inside while looking out onto the serene river, playing 20 questions. As we probed to discover what object the other had identified, we watched several flies struggle against the glass as they tried to get outside. It was beyond their intellectual capacity to understand the concept of glass and to improvise a plan to take an alternative route to get back where they belonged. In our normal gaze we look past the flies to the trees and the river. Kate and I wondered what else we miss moment to moment. Most of it, probably. We are powerful and weak, all-seeing and oblivious, free and trapped. The modern world is our glass. On Sunday morning I asked Kate to draw what she was feeling. She was reading a book and sketched onto the open page, which happened to be the dedication and read “sine qua non”, the one without whom, not. The quiet of the forest sharpened what I could notice. The flies on the window. Kate across the table. A dedication in a borrowed book that became, by accident, hers to me. Are all trapped behind glass we cannot see?

🚨 I HAVE NO MICROPLASTICS IN MY BALLS 🚨 This should not be possible. Studies show that 100% of men have microplastics in their semen. I am the first human ever to show a complete reduction to zero. This may be a world-first breakthrough in fertility research. I had 165 microplastic particles in my semen just 18 months ago. Now, I have zero. Five published studies have measured microplastics in human semen. Two found them in 100% of men. The other three found then in 44 to 76% of men tested, but those used methods that miss the smallest particles and the clear ones. Corrected for that, the real rate is likely 100%. Almost every man alive has plastic in his semen right now. The same applies to testicular tissue, testing 100% positive for microplastics. Microplastics hurt sperm. Human studies show the impact of various types of plastic, associated chemicals, and other toxins on male fertility: + 60% fewer normal shaped sperm (from PFAS) + 5x higher odds of low sperm count (from PTFE) + 10% lower sperm concentration (from PTFE) + 15% lower swimming ability (from PTFE) + 41% lower swimming ability (from PET) + 12% lower sperm swimming ability (from BPA) + 3x higher odds of low sperm count (from Phthalates) + 2x higher odds of poor swimming (from Phthalates) The effects compound: each extra type of plastic drops sperm swimming ability by about 21%. This matters even if you’re NOT trying to get pregnant. Sperm count is one of the cleanest biomarkers of overall health we have. And microplastics don't stop at the testes. The same particles are showing up everywhere we look. Studies show 4.5x higher rate of heart attack, stroke, and death in people with microplastics in their arterial plaque vs. those without. Microplastics were also found in 100% of human placentas tested. 100% of post-mortem human brains tested positive for microplastics. Brain concentrations rose ~50% between 2016 and 2024, and now sit at roughly 11x the levels found in the liver or kidney. Where do these come from? + PTFE, commonly in non-stick pans + PET, water bottles + Phthalates, makes plastic soft and bendy + BPA, can linings + PFAS, stain-resistant fabrics & food packaging Inside the body, plastic causes a kind of cellular rust. It triggers inflammation in the testicles, kills the cells that make sperm and drops testosterone. It's been confirmed across 39 animal and cell studies, then in human data. MY PROTOCOL: Note, what I did is n=1, not a controlled trial, I cannot prove cause. 1. Sauna (dry). My toxin blood panel confirms sauna clears plastic related chemicals: BPA, phthalates, PFAS, flame retardants, pesticides. The plastic particles themselves are too big to sweat out directly. Heat may activate other clearance routes: bile flow through the liver, the cell's internal cleanup system, and the gut barrier. Humans have almost no enzymes that can break plastic apart, so the body has to physically push it out. 2. Reverse osmosis water filter. Drinking water is likely a major source of microplastic getting into your body. A reverse osmosis filter pushes water through a very tight membrane and strains the particles out. I filter everything I drink. 3. Trying to rid my environment of the big plastic items: cutting boards, cups, plates, food storage containers, non-stick pans, cling wrap, tea bags, water bottles, kitchen utensils, kettles, and synthetic clothing. Note, as hard as I try, I'm always finding new plastic things in my life. This can be all-consuming thing so try to just knock out the big ones. I did all three interventions at the same time. I cannot say which one did the most work. What I can say is this: going from 165 to zero in 18 months is possible. Results: Nov 2024: 165 particles/mL Jul 2025: 20 particles/mL Apr 2026: 0 particles/mL The 18 month window also captures roughly 7 full spermatogenesis cycles.

Society was built to make money. Indifferent to your health and sanity. For example, we did not evolve to: + sit 10 hours a day + have our attention fractured 300 times daily + compare ourselves to millions of others + travel 9 time zones in 13 hours + tolerate sounds above 85 dB causing hearing loss + outsmart algorithms hijacking our reward system + breathe fine particulate air pollution + live under 16+ hrs of artificial light a day + have 3 courses of antibiotics before age 2 + eat ultra-processed foods for 60% of daily calories + consume 17 teaspoons of added sugar a day So if you're feeling down in the dumps, maybe fatigued, a little or a lot depressed, anxious, that's why.

People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295. It pushed my growth hormone up by ~8x. That’s good. That’s what it was supposed to do. But, it also came with adverse effects: > increased my morning fasted blood sugar up 20% > increased stress hormone by 12% > tanked my REM sleep by 23% > made my pancreas work 53% harder and was still losing to rising blood glucose > increased my insulin resistance by 50% These were the most obvious side effects, and I only ran a very narrow panel for this experiment. So I’m sure there’s more. I stopped after two doses, without even reaching the intended target dose. For those of you new to peptides, your body sends instructions to itself using tiny chemical messengers called peptides. There are thousands of them. For example, GLP-1s are drugs that take an existing class of short-lived peptides and modify them to extend their activity duration, which turns them into drugs, following rigorous clinical testing. CJC-1295 is one of those peptide-drugs. It tells your brain to release more growth hormone. Growth hormone is your body's signal to build muscle, repair tissue, and recover. However, and like most grey market peptides, CJC-1295 did not succeed its clinical trial, and hence never became an “official” drug. There is a version called CJC-1295 with DAC. DAC is an attachment glued onto the peptide that makes it last for days in your body instead of hours. One shot, longer effect, just like GLP-1s. Why people use it: more growth hormone could mean better recovery, leaner body, faster healing. The experiment I completed. Two injections a week of CJC-1295 with DAC: > 1.2 mg > 1.8 mg 48 hours after the first injection I was nearly comatose. It felt like severe jet lag, the type you’d feel after traveling nine time zones. My sleep was wrecked and I felt continuously awful. My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued. Why we chose CJC-1295 with DAC. Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, mixed with another peptide called Ipamorelin. We went with CJC-1295 with DAC instead as it has the most controlled studies. CJC-1295 with DAC has 2 controlled trials in healthy adults. Ipamorelin alone has 1 controlled trial in healthy adults, plus 1 study that failed when they tried it on bowel surgery patients. The mix of the two has zero controlled trials. On Ipamorelin, it copies a chemical called ghrelin, the one that makes you hungry. On its own it gives you a quick burst of growth hormone that fades fast. It does not keep your longer acting growth signal (called IGF-1) up. Clinics mix Ipamorelin with CJC-1295 no-DAC because the two together are supposed to work better. But we don’t know if that’s accurate because we don’t have trial data. This is a problem with peptides. Almost none of them have been tested properly. We are flying blind. Most of what people use is based on what someone said online, what a clinic claims, or what a friend reports from their subjective feelings. Peptides have the potential to be great when well-studied.

Lunch today. Here's the recipe and instructions: Pesto Veggies with Black Lentils and Sweet Potato 1–2 servings
 Prep: 15 min
 Cook: 25–30 min Total : 40–45 min Ingredients Veggie pesto: * 1 packed cup fresh basil leaves * 2 tablespoons olive oil * 2 tablespoons pine nuts * 1 small garlic clove * 1 to 2 tablespoons water, as needed Vegetables: * 1 cup cauliflower florets * 1 cup broccoli florets * 1/4 cup sliced red onion * 1 small garlic clove, minced * 1 cup cherry tomatoes, halved * 1 medium zucchini, sliced * 1 tablespoon avocado oil or and high smoke point oil Lentils and sweet potato: * 1 cup cooked black lentils, cooked in vegetable broth * 1 small sweet potato, peeled if desired and cut into cubes * Water for steaming or boiling Finishing: * 2 oz sliced black Kalamata olives * 1 teaspoon truffle oil, optional * Microgreens for garnish, optional Instructions: 1. Make the pesto * Add basil, olive oil, pine nuts, garlic, and a small splash of water to a blender or food processor. * Blend until smooth or slightly textured, depending on preference. * If needed, add a little more water to help it blend. * Taste and adjust seasoning if using salt. 2. Cook the lentils * Rinse the black lentils if needed. * Cook 1 cup of black lentils in vegetable broth according to package directions until tender but not mushy. * Drain any excess liquid if necessary and set aside. 3. Steam the sweet potato * Place the cubed sweet potato in a steamer basket or small pot with a little water. * Steam until fork-tender, about 10 to 12 minutes. * Set aside. 4. Sauté the vegetables * Heat 1 tablespoon oil in a large skillet over medium heat. * Add the red onion and garlic first and cook for 1 to 2 minutes. * Add cauliflower and broccoli and cook for 4 to 5 minutes. * Add zucchini and cherry tomatoes and continue cooking for another 4 to 6 minutes, until the vegetables are tender but still vibrant. 5. Combine with pesto * Turn the heat to low. * Add the pesto to the vegetables and stir well to coat everything evenly. * If the mixture is too thick, add a small splash of water to loosen it. 6. Assemble the dish * Spoon the cooked black lentils onto plates or into bowls. * Add the steamed sweet potato. * Top with the pesto vegetables. * Add sliced Kalamata olives over the top. * Drizzle with truffle oil if using. * Finish with microgreens for garnish. Serving Suggestion * Serve warm as a main dish for 1 hearty serving or as 2 lighter servings. * This dish also works well with extra lemon juice on top if you want brightness. Health Benefits * Black lentils provide plant-based protein, fiber, iron, and slow-digesting carbohydrates that support fullness and steady energy. * Broccoli and cauliflower supply vitamin C, vitamin K, and glucosinolates, which support antioxidant and detoxification pathways. * Zucchini, tomatoes, red onion, and garlic add antioxidants and phytonutrients that support overall cellular health. * Sweet potato provides beta-carotene, potassium, and fiber, supporting immune and digestive health. * Basil, pine nuts, and olive oil contribute healthy fats and aromatic compounds that support satiety and flavor. * Kalamata olives add heart-healthy monounsaturated fats and a savory finish. * Microgreens add concentrated micronutrients and a fresh garnish.