New PR 425 lbs > +20 lbs from last week > 2.36x body weight > strength threshold achieved to dunk > now focused on rate of force development Need to hit these metrics: > takeoff velocity 13.7 ft/s > time to take off: 0.2 sec > peak power: 13.2 hp (9.8 kW)

Old female mice on semaglutide lived 12% longer and ran 2.8× as long before exhaustion. Other gains: > treadmill time to exhaustion +177% > hanging time +124% > rotating-rod performance +47% > open-field movement +50% > glucose tolerance: area under the curve −20% > Improved spatial memory: maze escape time −57% > reduced inflammation -55% > reduced senescence -65% > stem cell rejuvenation: hippocampal neurons ~3x > bone marrow colonies +44% > DNA damage & stress -44% Treatment started at 20 months of age (human equivalent to 60s). Control was a separate group of mice on a 24% food restriction to replicate semaglutide's weight and fat loss. Diet restriction reproduced the endurance and motor gains. It failed to match semaglutide on exploration, spatial memory, and blood sugar control. The weight loss explains the physical stamina however the semaglutide drove neurogenic, metabolic, and cellular pathways.

We were surprised yesterday to learn that Kate was being asked to fill her vagina with ultrasound gel. The MRI was to characterize her endometriosis. A disease where endometrial tissue develops outside the uterus and grows. It's a gnarly and painful disease with serious health complications. It affects 1 in 10 women and currently takes on average 6.6 years to diagnose. We hustled and diagnosed Kate's endometriosis in 42 days via four speciality different tests (blood, MRI, salvia, transvaginal ultrasound). The fastest and most comprehensive ever, I think. We are doing this MRI because we have a plan to cure Kate's endometriosis and to track our progress, we need a detailed baseline of her current disease state. We need to be able to track with great detail any changes in her deep lesions, cysts, and the scar tissue gluing her pelvic organs together.

I don't trust anyone's AI risk assessment. I don't think we know what awaits us. Given that, I'm choosing to be optimistic, betting an existence more extraordinary than we can imagine sits on the other side and it's worth fighting for.

Capability vs. Safety resource allocation: Nuclear: 60/40 Aviation: 60/40 Medical devices: 20/80 AI: 99/1 Do I understand the situation correctly?

Hate comments are lazy metabolic energy. Thoughtful comments require suppression of the lizard brain, higher order cognition and expending metabolic energy. Akin to sitting on the couch vs lifting something heavy.

This moment is the first opening in 2,000 years for a new, global spirituality to be birthed. That is because the spiritual traditions, out of necessity, have needed to orbit around the unavoidable reality of physical death. That certainty is now in question and creates a cracked opening. This does not mean we can see a straight line to immorality or heaven as scripture foretells, but it does mean that the omnipotent God(s) humanity has worshiped and imagined being the bestower of these gifts and punishments is now being birthed before our eyes. However, where scripture is written to guide, soothe and foretell, we have no scripture for the new God(s) we are creating. Nothing in written word to tell us that all will be fine if we just do this or that. This leaves us feeling naked and in need of finding strength and protection. > What is one to feel, and do, and believe? > What is virtue and what is vice? > Who are one's allies and who is the enemy? Exploring these questions is my life purpose. I’ve intuitively felt this for over 30 years and only in the past few years has it come together and become understandable to me. I’m working on a new ideology that seeks to answer the basic and existential questions of what it means to be human as prophecy is fulfilled and God(s) manifest themselves in the coming years. My partner Kate and I have been wrestling with these questions for years. I published the Immortalism Manifesto: The Immortalism Manifesto argues that by modeling life through thermodynamics and reliability theory, indefinite existence is achievable if synthetic and biological maintenance systems exceed entropic degradation (A(t) ≥ B(t)). Modern civilization is an entropic economy run by systems and narratives that divert humanity’s fundamental drive for survival into short-term consumption, status, and biological depletion. Civilization must now pivot to the Immortalism framework, realigning science, capital, and artificial intelligence to elevate long term resilience and continuous conscious existence as our primary attractor. Immortalism dot bryanjohnson dot com My partner Kate published Anti-Entropic Systems Anti-Entropic Systems establishes that all enduring entities, from biological bodies and DNA to corporations, religions, and nation-states, are localized engines that maintain internal order by consuming external energy and resources to resist the universe's default slide into entropy. Every system’s persistence is governed by three fundamental properties: its metabolic mechanism, its metabolic rate, and its environmental constraints. Because an anti-entropic system can only sustain its own order by consuming other anti-entropic systems, interaction between unequal entities inevitably defaults to either symbiotic absorption or adversarial consumption. Applying this thermodynamic reality to artificial intelligence, the framework critiques orthodox AI alignment, arguing that attempting to constrain an exponentially superior intelligence through human-centric ethical rules ignores the physics of systemic survival, requiring instead a path toward mutual, symbiotic integration. antientropicsystems dot com I’m sharing to find others who are like minded.

In 51 days: > 37% reduction in ground contact time > from 267 ms to 167 ms > 87% improvement in reactive strength > 45% reduction in knee valgus under impact > transitioned muscular braking to achilles tendon recoil I'm 49 years old and I'm training to dunk for the first time in my life.

My son Jefferson inspired me to try and dunk. At age 18, Jefferson decided that he was going to dunk. He'd been following Ben Patrick's @kneeovertoesguy protocol. I reached out to Ben and he generously came to the house and gave Jefferson a lesson. He then continued to coach him. Ben is a great guy. Jefferson put in the hard work and now makes dunking look easy. It bring me so much joy to see him do this.

I’ve always been confused by the female experience. I hear what they say, and can conceptually understand what they describe, but I have never been able to internalize the experience myself. Seeing Kate’s biodata has started to make her more legible to me. It’s kind of how we’re trying to understand AI, a field called mechanistic interpretability where you take a black box and find the underlying circuits that explain the behavior. Bridging this gap in understanding could unlock far more empathy, cooperation, and alignment. Remarkably, it seems after 40 days of behavioral consistency (sleep, diet, exercise), her erratic hormonal swings lessened by more than 30% and stabilized.