Organoids are full of cells that shouldn’t be there, and sorting them out wrecks the vasculature. SynBITE prunes in place instead. #longevity# #geroscience# #SynBITE# #organoids# #biotechnology#

There's been steady progress using organs in a dish—organoids— for medical research. But now there's the immunoid to enhance our understanding of the complex immune system in people, and at the individual level. @CellStemCell .

This year, we captured our @Stanford @BrOrganogenesis hand-on workshop on human stem cell models course in action. Every year here on campus, we share methods developed in our lab for generating and applying neural #organoids# and #assembloids#. Mornings are devoted to lectures, while afternoons are spent at the bench: going from building assembloids to imaging them and recording their electrical activity. Throughout the week, students also work together in small groups on a project. This year, by popular demand, we focused on assembloids This spring, 22 students came from around the world. They returned to their institutions and labs taking these methods with them and adapting them to their own research. For us, the course is an invigorating lab-wide effort that we prepare for months in advance. This year it was superbly organized by three outstanding scientists: Merve Avar, Sabina Kanton, and Rebecca Levy (who recently started her own lab at Stanford!). One of the best weeks of the year for us in lab. A glimpse of it in the video below.

Endpoint assays give you a single time point. Resipher works with standard 96-well plates to give you the full metabolic picture - captured continuously while your organoids and spheroids stay in the incubator. Ready to accelerate your research? Request a virtual demo today!

SpaceX has introduced a new website for Starfall, which enables affordable, routine access to a microgravity environment, providing unique opportunities for manufacturing, scientific research, and testing in low-Earth orbit. Starfall specs: • Payload capacity: 1,000 kg (2,205 lbs) • Payload power: 1 kW • Data interface: Ethernet • Mission duration: Customizable to payload requirements • Connectivity: Continuous via Starlink SpaceX says Starfall is for: • Biomedical Research: Developing advanced biomaterials, medical implants, stem-cell organoids, and replacement tissues. • Pharmaceutical Discovery: Growing more uniform protein and drug crystals in microgravity to accelerate drug development. • Materials Science: Manufacturing next-generation materials and semiconductors using the vacuum and microgravity environment of space. Website:

An AI model just rediscovered Kepler's law from latent space, with zero knowledge of orbital mechanics. And the same core architecture spans molecular dynamics, cell prediction, and even generating cancer treatment hypotheses. Title: JEPA-Anything: Learning Predictive Models across Different Worlds URL: In one sentence: it decomposes a target's representation into K orthogonal subspaces, each with its own dedicated predictor — "Orthogonal Predictive Factorization" (OPF) — and applies this single mechanism across radically different domains, from vision and biology to clinical data, control, and molecular dynamics. 🔭 Highlight 1: Rediscovering a physical law from latent space Trained only on orbital motion data, its latent frequency modes recovered Kepler's law f=(2π)⁻¹a⁻³/². The fitted slope was -1.4991 against a theoretical -1.5, with R²=0.9999999. 🧬 Highlight 2: Generating and validating a cancer treatment hypothesis Factor analysis on liver cancer data proposed combining IL-18 and CD73 blockade, which then showed the strongest tumor cell killing in actual patient-derived organoids. ⚛️ Highlight 3: Consistently strong across molecular dynamics and cell prediction It achieved the lowest error across 100-step molecular simulations of water, quartz, paracetamol, and benzene, and also beat prior methods on single-cell perturbation prediction. It's striking that one core architecture spans such wildly different scientific domains this well. #WorldModels# #AIforScience#

How do genetics and the environment intersect in eczema and other skin diseases? @drsarabrown, @EdinburghUni, shares insights on human skin organoid models, gene–environment interactions, and the future of personalised dermatology. 🔗:

The latest in man made horrors beyond comprehension, scientists genetically engineered mice missing 50% of their brain then cut their skulls open and injected them with human brain cells that grew and colonized 90% of their cortex, forming a human-mouse hybrid. The scientists are calling it “xenocortication” because it’s not just the human brain organoid taking up space. It actually partially restored function that the genetically altered missing-brain mice lost, with the human brain cells forming neurons into the mouse brain cells and integrating into it. Then for some of the xenocortex mice they suffocated them in a low oxygen box to give them brain damage, just to see how crippled up they would become! I guess it’s a way of studying human brain development but I feel like this is way beyond the line of ethical research. I don’t see why doing something like this to another living creature, especially in the context where an animal research ethics board reviewed it. Stanford’s Institutional Animal Care and Use Committee and Stem Cell Research Oversight committee both signed off on this.