Sentinel Bio's @jtmonrad reveals their "victory condition" approach to grant-making: "The most important part of how we operate at Sentinel is setting what we would call the victory condition. The end state of the world that we would like to see. I work on biosecurity, so you say by 2030 it should be the case that if you're a legitimate scientist wanting to do bioscience, you can access really powerful models very easily." "But if you're some rogue terrorist group or unhobbled agent swarm trying to buy DNA online or use Mythos-7, there's gonna be some friction." "You set that end state, and then we reason backwards from what has to be true to get there. This is very different from a forward-looking way of doing grant-making where you receive some proposals, and others tell you where they would like to go, and then you evaluate who has the best plan." "What it gives you is the ability to say, this organization needs to exist to get us to the victory condition. Now let's go find the best person to do that."