伟哥又多了抗癌的效果
最新研究显示,它能提高 cGMP 水平,从而阻断胆固醇转运蛋白 NPC1。这会使胆固醇被困在溶酶体内,导致癌细胞缺乏迁移和形成转移所需的胆固醇。
想到吃药后的副作用…
Sildenafil (Viagra) may help stop cancer from spreading.
New research shows it raises cGMP, which blocks the cholesterol transporter NPC1. This traps cholesterol inside lysosomes, starving cancer cells of the cholesterol they need to migrate and form metastases.
Cancer cells are especially sensitive to this effect. Combining it with statins strengthens the result. Real-world health records also link sildenafil use to better survival in cancer patients.
A surprising new role for an old drug.
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