$MRNA surged 108% in premarket trading after delivering what could be a defining milestone for mRNA beyond vaccines.
Moderna and Merck's personalized mRNA cancer therapy met both the primary RFS endpoint and key secondary DMFS endpoint in Phase 3 melanoma, showing statistically significant and clinically meaningful improvements over Keytruda alone.
This marks the first positive Phase 3 readout for an individualized neoantigen therapy — and for any mRNA-based cancer therapy.
Full data are still to come, with Moderna and Merck now preparing to engage regulators on potential filings.
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