Top 99.8 percentile of healthy 20 yr olds > eHbA1c 4.4% > elite among elite > new personal best Blood glucose is the body's circulating fuel supply. Why this marker matters: Spikes/high levels: > rust blood vessels > damage heart > accelerate organ aging > strain pancreas > trigger cellular inflammation Steady levels: > sharpen cognition > protect arteries > preserve organs > powers deep sleep > stable energy What to do: 1) fast 14-16 hrs daily 2) build muscle with heavy lifting 3) walk after eating or air squats every 45 min 4) no added sugar 5) prioritize sleep

Old female mice on semaglutide lived 12% longer and ran 2.8× as long before exhaustion. Other gains: > treadmill time to exhaustion +177% > hanging time +124% > rotating-rod performance +47% > open-field movement +50% > glucose tolerance: area under the curve −20% > Improved spatial memory: maze escape time −57% > reduced inflammation -55% > reduced senescence -65% > stem cell rejuvenation: hippocampal neurons ~3x > bone marrow colonies +44% > DNA damage & stress -44% Treatment started at 20 months of age (human equivalent to 60s). Control was a separate group of mice on a 24% food restriction to replicate semaglutide's weight and fat loss. Diet restriction reproduced the endurance and motor gains. It failed to match semaglutide on exploration, spatial memory, and blood sugar control. The weight loss explains the physical stamina however the semaglutide drove neurogenic, metabolic, and cellular pathways.

Kate’s period will start any minute now…. I’ve been waiting for 34 days. This is historic; the most measured menstrual cycle in history. What we’ve measured so far: > 408 min of brain data > 10k blood glucose readings > 48,960 core body temp readings > 136 photos of her body > much more.. see below In total, 14 million data points. Full list of what we’re measuring: > core body temp via ingested pill > pain threshold > grip strength > photograph of the body > body thermal temperature > blood pressure > weighing menstrual blood > cortisol > blood glucose > DNA methylation > oral microbiome > stool microbiome > urine metabolites for hormones > stool microbiome > vaginal microbiome > cervical mucus > sleep > wearable > resting metabolic rate > metabolism. > techno-tampon, for lady boners > reaction time > skin biological age > brain with Kernel > breast measurement > urine concentration > hormone concentration > weight > nutrition proud of @_katetolo for becoming the world's most measured woman

Zinc supplementation improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, even though it didn't clearly lower blood glucose. This fits with the biology of zinc. Inside the pancreas, it helps insulin molecules assemble into compact structures so they can be safely stored and released when blood glucose rises. Zinc also supports insulin signaling and antioxidant defenses, both of which can become disrupted in diabetes. This doesn’t mean everyone should supplement. Any benefit may depend heavily on whether someone is getting enough zinc in the first place, while excessive zinc intake carries risks of its own (like interfering with copper absorption).

Coffee consumption linked to healthier body composition and metabolic markers. People with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass. In men, it is linked to a more favourable glucose–insulin profile, and higher bioavailable testosterone.

Throughout their first two full days on-orbit, the crew took the first-ever X-ray in space, 130 years after the first X-ray was captured. The @framonauts did a brain mapping EEG experiment and contributed to a continuous glucose monitor study examining how fluid shifts in space affect the accuracy of glucose monitors for diabetics. Chun, Jannicke, Rabea, and Eric also transferred images for Fram2Ham, took conference calls in space, and were able to chat with their families thanks to @Starlink

In many ways, I am 18. If an alien encountered me, they’d struggle to distinguish me from my son. I know this seems impossible. I also know I look my age, 49. But here are the ways I am indistinguishable from an 18 year old: > Sleep quality > Erection function > Fertility > Resting heart rate > Vascular health > Cardiovascular health > Blood pressure > Metabolic health > Blood glucose control > Bone mineral density > Muscle > Fat > Inflammation (undetectable) > Shitposting And here are some ways I am my age: > Hearing > Somatic mutations Friends, I think I’ve done something no one else has ever done: I am more 18 than I am 49. This is the first rep and we are still figuring things out, but it points toward our inevitable future: better technology and therapies will make youthful vibrance the default. If you’re in your 30s, 40s, 50s, 60s, and wondering if you can do the same, the answer is yes. If you’re a teen or in your 20s and feel awful, you can too. These results only took me 5 years to achieve. The most powerful things are free, and gated only by choice. It feels amazing. I feel nimble, and spry, and excited by the world. I hope you join me in saying yes to life and no to die culture.

🚨 New research shows fructose, helps cancerous tumors spread. When chemotherapy damages ovarian cancer cells without completely destroying them, some enter a state known as senescence, where they stop dividing but remain biologically active. A new preclinical study from The Wistar Institute has revealed that these surviving cells produce and release fructose, which neighboring cancer cells readily absorb. This absorption alters the way target cells process energy and dramatically lowers cholesterol in their outer membranes. Since cholesterol acts as a vital cellular glue keeping cells anchored together, this depletion allows neighboring cancer cells to detach and easily spread throughout the abdominal cavity. In animal trials, mice given high levels of fructose in their drinking water developed significantly more metastatic nodules than those given glucose. Furthermore, clinical samples from patients with high-grade serous ovarian cancer showed a correlation between elevated circulating fructose levels and advanced stages of the disease. While researchers caution that these preclinical findings do not mean eating fresh fruit causes cancer to spread—as whole fruit contains fiber and other vital nutrients—the discovery opens a promising new avenue. Scientists are already investigating if this fructose-driven mechanism also fuels the progression of pancreatic, colon, and liver cancers. source: Cole, A. R., et al. (2026). The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming. Nature Aging.

Massive blood draw today: > 47 tubes > 250 mL What I'm measuring: > single cell sequencing of circulating immune cells > inflammation, oxidative stress, vascular health > metabolic, lipid, blood glucose regulation > brain