Top 99.8 percentile of healthy 20 yr olds > eHbA1c 4.4% > elite among elite > new personal best Blood glucose is the body's circulating fuel supply. Why this marker matters: Spikes/high levels: > rust blood vessels > damage heart > accelerate organ aging > strain pancreas > trigger cellular inflammation Steady levels: > sharpen cognition > protect arteries > preserve organs > powers deep sleep > stable energy What to do: 1) fast 14-16 hrs daily 2) build muscle with heavy lifting 3) walk after eating or air squats every 45 min 4) no added sugar 5) prioritize sleep

Eight stories show where longevity is gaining momentum, from Alzheimer’s and Parkinson’s to biomarkers and glucose sensing. Not every headline is a breakthrough, but each is worth checking. Read more at #longevity# #geroscience# #biomarkers#

Social stress costs you 104 calories per meal: Your brain runs a budget for your body, and it is budgeting glucose, salt, oxygen and water. Get socially stressed within two hours of a meal and you metabolize that food less efficiently, burning the equivalent of 104 extra calories. Over a year that is 11 pounds. Being with a friend you trust runs the other way: everything you do is slightly less metabolically expensive. @LFeldmanBarrett on @hubermanlab

Best foods for reducing belly fat that have nothing to do with calorie restriction: - Apple cider vinegar before meals — improves insulin sensitivity and reduces postprandial glucose spikes - Fermented foods daily — gut dysbiosis is independently linked to visceral fat accumulation - Omega-3 rich fish — EPA and DHA reduce the cortisol-driven inflammation that causes preferential belly fat storage - Protein at 30 to 40 grams per meal — the thermic effect of protein burns 20 to 30% of its own calories in digestion - Cruciferous vegetables — DIM reduces estrogen dominance which drives fat storage around the midsection

Old female mice on semaglutide lived 12% longer and ran 2.8× as long before exhaustion. Other gains: > treadmill time to exhaustion +177% > hanging time +124% > rotating-rod performance +47% > open-field movement +50% > glucose tolerance: area under the curve −20% > Improved spatial memory: maze escape time −57% > reduced inflammation -55% > reduced senescence -65% > stem cell rejuvenation: hippocampal neurons ~3x > bone marrow colonies +44% > DNA damage & stress -44% Treatment started at 20 months of age (human equivalent to 60s). Control was a separate group of mice on a 24% food restriction to replicate semaglutide's weight and fat loss. Diet restriction reproduced the endurance and motor gains. It failed to match semaglutide on exploration, spatial memory, and blood sugar control. The weight loss explains the physical stamina however the semaglutide drove neurogenic, metabolic, and cellular pathways.

Kate’s period will start any minute now…. I’ve been waiting for 34 days. This is historic; the most measured menstrual cycle in history. What we’ve measured so far: > 408 min of brain data > 10k blood glucose readings > 48,960 core body temp readings > 136 photos of her body > much more.. see below In total, 14 million data points. Full list of what we’re measuring: > core body temp via ingested pill > pain threshold > grip strength > photograph of the body > body thermal temperature > blood pressure > weighing menstrual blood > cortisol > blood glucose > DNA methylation > oral microbiome > stool microbiome > urine metabolites for hormones > stool microbiome > vaginal microbiome > cervical mucus > sleep > wearable > resting metabolic rate > metabolism. > techno-tampon, for lady boners > reaction time > skin biological age > brain with Kernel > breast measurement > urine concentration > hormone concentration > weight > nutrition proud of @_katetolo for becoming the world's most measured woman