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Tweets including neutrophils
New work involving mice and patient cells reveals the mechanisms behind how neutrophils drive a rare group of autoinflammatory disorders called CAPS—and uncovers a potential new therapeutic target. @SciSignal
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New work involving mice and patient cells reveals the mechanisms behind how #neutrophils# drive a rare group of autoinflammatory disorders named CAPS—and uncovers a potential new therapeutic target. @UCSanDiego
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How do inflammasomes drive CAPS?
A mass cytometry analysis decrypts how #NLRP3# mutations in patient neutrophils trigger the clustering of gasdermin D and E at the plasma membrane, leading to #pyroptosis# and the release of IL-1-beta. @UCSanDiego
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How do inflammasomes drive CAPS?
A mass cytometry analysis decrypts how #NLRP3# mutations in patient neutrophils trigger the clustering of gasdermin D and E at the plasma membrane, leading to #pyroptosis# and the release of IL-1-beta. @UCSanDiego
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This week’s new issue of #ScienceSignaling# has arrived!
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more.
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Nature research paper: T and B cells recognize splicing-derived neutrophil neoantigens in lupus
