The Vaccines Targeted the Most Mutable Part of the Virus
Spike is the FASTEST-CHANGING region of SARS-CoV-2 — heaviest immune selection pressure, which is why variants are named for changes in it. Nucleocapsid and envelope are far more conserved. Build every vaccine around spike alone and the target moves. By late 2021 studies found SIMILAR PEAK VIRAL LOADS in vaccinated and unvaccinated. That’s what non-sterilizing means. Pan-coronavirus work has since turned to the conserved proteins.
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