Matthew Herper(@matthewherper):Call it the mystery of Moderna’s magic algorithm. The company's therapeutic cancer vaccine, intismeran autogene, would be the first approved medicine whose genetic instructions — that is, the individual letters of its mRNA — is determined by a computer. "I have no idea” what’s in Moderna’s algorithm, one expert says. But we have some clues. Also: What the head of R&D at Merck says about the idea that perhaps the efficacy is not due to the algorithm at all -- but just to the effects of an mRNA lipid nanoparticle. https://t.co/VJ9PvVTbxr By me, @Jasonmmast and @angRchen $MRNA $MRK

2026.08.27 12:36

Call it the mystery of Moderna’s magic algorithm. The company's therapeutic cancer vaccine, intismeran autogene, would be the first approved medicine whose genetic instructions — that is, the individual letters of its mRNA — is determined by a computer. "I have no idea” what’s in Moderna’s algorithm, one expert says. But we have some clues. Also: What the head of R&D at Merck says about the idea that perhaps the efficacy is not due to the algorithm at all -- but just to the effects of an mRNA lipid nanoparticle. By me, @Jasonmmast and @angRchen $MRNA $MRK