LNPs are transforming precision cancer therapy with smarter, targeted delivery. Join us at (OTDC – May) 25–26, 2026 in Rome, Italy to explore next-gen oligonucleotide innovation. 🔗 #LNP# #OTDC2026# #mRNAtherapy# #siRNADelivery#

Breaking the mold with #RNA—a# “ #RNAissance# ” of life science. . #RNAtherapeutics# #RNAdrugs# #Oligonucleotides# #mRNAtherapeutics# #mRNA# #siRNA# #RNAi# #Antisenseoligonucleotides# #Antisenseoligonucleotides# #ASO# #NucleicAcids# .

Tomorrow at #ESMO26#: MSK gastrointestinal medical oncologist @AndreaCercek will present the first results from the global AZUR1 trial of dostarlimab monotherapy in patients with dMMR/MSI-H locally advanced rectal cancer. 🗓️ Sunday, October 25 | 11:00 a.m. CET

PMV PHARMACEUTICALS $PMVP REPORTS 46% ORR IN OVARIAN CANCER TRIAL Updated interim data from the PYNNACLE Phase 2 pivotal trial of rezatapopt monotherapy, per the company. - Objective response rate: 46% among 76 ovarian cancer patients - Median time to response: 1.3 months - Median duration of response: 10.0 months - Discontinuation rate due to adverse events: 5%

Hear me out. On paper COMMIT is a "Positive" trial. It is also a spectacular demonstration that Atezolizumab monotherapy should never be used for metastatic MSI-H CRC (we can talk about adjuvant). COMMIT was a randomized first-line study in metastatic MSI-H/dMMR CRC. It began as a 3-arm trial of: • mFOLFOX6/bevacizumab (this sucks) • atezolizumab alone • mFOLFOX6/bevacizumab/atezolizumab After KEYNOTE-177 changed the standard of care, the chemotherapy-only arm closed after 20 patients. The trial continued with 82 patients randomized between atezo alone and the four-drug combination. The headline is that adding FOLFOX/bevacizumab to atezo improved PFS: HR 0.42 Median PFS: 24.5 vs 5.3 months ORR: 86% vs 46% Primary progression: 2.8% vs 32.4% The truth is Atezolizumab PALES in comparison to its contemporary PD1/PDL1 agents in this setting. Single-agent atezo: 12-month PFS 35% 24-month PFS 32% For comparison: Pembrolizumab in KEYNOTE-177: 12-month PFS 55% 24-month PFS 48% Nivolumab in CheckMate 8HW: 12-month PFS 63% 24-month PFS 56% This is not evidence that every patient with metastatic MSI-H CRC needs chemotherapy, bevacizumab, and immunotherapy. It is evidence that NO ONE SHOULD BE USING ATEZOLIZUMAB IN METASTATIC MSI-H CRC. And now, drumroll please… The only positive randomized adjuvant immunotherapy strategy in stage III dMMR colon cancer is ATOMIC: FOLFOX + atezolizumab. That makes COMMIT more than a roast. It raises a important question about ATOMIC. Should we be using Atezolizumab in the adjuvant setting? Do we need to be giving chemotherapy here? Looking forward to what others make of this but this is the real question. @TheGutOncLab @OncoAlert @oncodaily

World Lung is in full swing, which means the press releases are coming fast (before the papers or the sessions). 🫁 Why do we care in GI? Because all the shiny things start in lung and eventually make their way over here. HARMONi-2 compared ivonescimab vs pembrolizumab in PD-L1+ advanced NSCLC. We already knew the PFS result was kind of wild (in a China-only study): 11.1 vs 5.8 months HR 0.51 Now OS: 🔥 30.8 vs 22.6 months 🔥 HR 0.73 PD-L1 ≥50%: HR 0.58 PD-L1 1–49%: HR 0.85 So now this PD-1 x VEGF bispecific has beaten pembrolizumab for both PFS and OS in a randomized phase III trial. Yes, China only. Yes, pembro monotherapy is not really the comparator most of us would want for PD-L1 1–49%. Still. An 8-month OS difference is quite a bit. GI oncologists should be paying attention because this is already cooking in the first line mCRC setting with HARMONi-GI3. mFOLFOX6 + ivonescimab vs mFOLFOX6 + bevacizumab Is this an end-run around patent protection laws and PD1/PDL1's run out of time? (yes) Does the strategy have synergystic benefit? Time will tell. @OncoAlert @TheGutOncLab @Onco_Nexus

🚀 Advances in targeted drug delivery are boosting oncotherapy by improving RNA, siRNA, ASO & CRISPR delivery for cancer treatment! 🌍 Join us at OTDC 2026 📅 25–26 May 2026 | Rome, Italy 🔗 #OTDC2026# #DrugDelivery# #Oncotherapy# #RNAtherapy# #Biotech#