RNA Therapeutics and Oligonucleotides
@RNAtherapeutic
#RNAtherapeutics#, #mRNAtherapeutics#, #mRNA#, #RNAediting#, #RNA#, #siRNA#, #RNAi# #ASO#, #AntisenseRNA#, #LipidNanoparticles#, #Drugdelivery#, #RNAdrugs#, #RNAmetabolism#
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Very excited to share our paper out today in @naturemethods, introducing TREX (Targeted RNase H-mediated Extraction of X-linked RBPs), a novel approach to reveal proteins that bind to any region of any RNA molecule of interest in living cells🧪: (1/10)
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Interesting Read: Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS #oligonucleotides#
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Narrowing down the candidates of beneficial A-to-I #RNAediting# by comparing the recoding sites with uneditable counterparts.
#ADAR#
#RNAtherapeutics#
#AstraZeneca# and #IonisPharmaceutical# are the first to receive FDA approval for the #antisenseoligonucleotide# (ASO) based RNA drug #eplontersen#.
The only treatment for the treatment of PN transthyretin-mediated amyloidosis (hATTR-PN).
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#RNAtherapeutics#
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An interesting review by #Moderna# Scientists.
How nucleotide sequence, nucleotide modification & #RNA# structure interplay to affect translational efficiency & mRNA stability to maximize the production of therapeutic proteins from #mRNA#.
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@NatRevDrugDisc
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How does cellular stress affect #RNA#? We sequence entire RNA molecules with @nanopore sequencing. We find 👉Global RNA decay mediated by XRN1, independent of poly(A) tail! 👉Decay absolutely depends on stress-granule formation!
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Don’t miss tomorrow’s talks 👇🏼
Do mRNA vaccines have impuritirs?
Does IVT transcribed mRNA is co-purified with double stranded RNA species?
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Enzymatic isolation and microfluidic electrophoresis analysis of residual #dsRNA# impurities in #mRNA# vaccines and therapeutics.
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Starting this session with Sergey Melnikov (Newcastle University), on the fascinating fate of RNAs and RNA regulatory proteins during prolonged state of metabolic inactivity (hibernation). Cells do have hibernation factors that protect Ribosomes from degradation!
#RNAUK2024#
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Super proud of my student Bibo Yang @Bibo00128791 who delivered a very nice flash talk #RNAUK2024# @DingLab_RNA #imotif#
Advances in Sustainable #Oligonucleotide# Manufacturing
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#Oligonucleotides#
#RNAtherapeutics#
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Almost ready to start day 3 of #RNAUK2024#!
Fantastic talks and posters so far, let's keep the fun going !
Today's morning session: Ribosomes and translation.
Breaking the mold with #RNA—a# “ #RNAissance# ” of life science.
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#RNAtherapeutics#
#RNAdrugs#
#Oligonucleotides#
#mRNAtherapeutics#
#mRNA#
#siRNA#
#RNAi#
#Antisenseoligonucleotides#
#Antisenseoligonucleotides#
#ASO#
#NucleicAcids#
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Hey hey #RNA# friends! this is @RekadZeinab taking over :). We are less than 24h away from #RNAUK2024#! Safe travels to everyone, and for those who can't attend: fear not, @aliceaoc and myself will do our max to bring you best of the event live under #RNAUK2024#!
Spread the word :)
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Don’t miss the next What can #RNA# do? Online Seminar series this January 29th 16h-18h EDT. This month’s topic: RNA in #condensates#. See details below and register!
Please checkout our most recent work where we explore the important parameters for self-assembled SNAs to deliver oligotherapies! Super excited to finally see this work out with my friend @JathAsoh ! Congratulations to all authors and @trishalina_das @SleimanHanadi . Go SNAs!
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I had the opportunity to present our work on therapeutic delivery of #mRNA# via #extracellularvesicles# and #lipidnanoparticles# as an invited speaker at @PLUS_1622. Excited to see great enthusiasm by the audience with burning questions and discussion around the topic. Keep building
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mRNA, rRNA, and tRNA might look different from each other in textbooks, but their difference only comes down to nucleotide sequence.
Learn more at
#biology# #3D# #animation# #education# #EdTech#
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Big news in the world of programmable mRNA therapy! We received FDA IND clearance for STX-001, our programmable #mRNA# therapy to treat solid tumors. Phase 1 trials are now underway. #mRNA# #ClinicalTrials# #Oncology# #ProgrammableMedicines#
Read our release:
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#Extracellularvesicles#, genetic programmers.
Next delivery systems for #RNAtherapeutics#
#Exosomes#
