Depression is a metabolic illness: A bankrupt body budget. So fatigued you can't move and so distressed you can't think your way out. Look at the symptoms and they are metabolic deficits. One hallmark is the loss of positive anticipation about the future. If you feel unpleasant you won't predict anything pleasant, and learning from prediction error is expensive, so even the things that could give you pleasure go unnoticed. @LFeldmanBarrett on @hubermanlab

Dietary composition and metabolic stress differentially affect the ovarian microenvironment in mice "These findings support ovarian stromal fibrosis as a potential early feature of diet-associated ovarian remodeling and reproductive aging."

Hate comments are lazy metabolic energy. Thoughtful comments require suppression of the lizard brain, higher order cognition and expending metabolic energy. Akin to sitting on the couch vs lifting something heavy.

Only 6.8% of Americans are metabolically healthy... That means 93.2% of us are walking around with some form of metabolic dysfunction: high blood sugar, high blood pressure, abnormal cholesterol, obesity, or a history of heart attack or stroke. And the primary culprit is ultra-processed food loaded with sugar and starch. This epidemic is devastating our health and it’s bankrupting our nation: -The U.S. government now spends $4.9 trillion on healthcare. -$2 trillion of that is completely preventable, driven by food-related chronic diseases. -And 1 in every 3 taxpayer dollars goes directly toward this broken system… We’re wasting trillions that could be used for education, infrastructure, innovation, and real public health reform. Meanwhile, we’re bombarded with “quick fixes” like weight-loss drugs that don’t treat the root cause. I’ve had patients lose just 2 pounds in 6 months on GLP-1s, with side effects. Another patient lost 60 pounds, reversed their diabetes, and reclaimed their health with FOOD. No miracle pill can outcompete a lifestyle built on quality nutrition, movement, and metabolic healing. This isn’t complicated, but the noise is loud. The marketing is powerful. And the truth is getting buried… You don’t need a fad diet or pill, you need real food, accountability, and the belief that your body can heal.

EXPRESS: Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial "These findings suggest that rapamycin may mitigate early cerebrovascular and systemic dysfunction in APOE4 carriers and support a precision medicine approach in which therapeutic response is influenced by genotype."

Coffee consumption linked to healthier body composition and metabolic markers. People with higher coffee consumption had lower total and visceral fat and greater skeletal muscle mass. In men, it is linked to a more favourable glucose–insulin profile, and higher bioavailable testosterone.