This is freaking huge: For the first time, a AI-assisted personalized mRNA cancer treatment has succeeded in a Phase 3 trial. Moderna and Merck sequence each patient’s tumor and compare it with their healthy DNA. AI then helps identify which of the tumor’s mutations are most likely to trigger an immune response. From those targets, Moderna produces an individual mRNA treatment encoding up to 34 neoantigens, The earlier Phase 2 trial followed patients with surgically removed high-risk melanoma for five years: - 68.8% remained cancer-free, compared with 49.1% on Keytruda alone - 49% lower risk of recurrence or death - 59% lower risk of distant metastasis or death Now the much larger Phase 3 trial involving 1,137 patients has also succeeded. Absolutely incredible. Dario was right: cancer will be cured in just a few years!

The models are improving the models. Locus, our automated AI research system, is SOTA on PostTrainBench and post-trains Qwen3 base models that surpass the human post-trained Qwen3 model. Today, LLMs post-trained end-to-end by Locus are in production to millions. 🧵👇 PostTrainBench evaluates agents' ability to post-train models on various domains given 10 H100 hours. We extend PostTrainBench via PostTrainBench+, which has a greatly expanded compute budget that provides clearer signal on automated post-training capabilities. We find that thousands of H100 hours help distinguish methods' performance post-training Qwen3 1.7B-Base models, and that Locus scales best. In this setting, modes trained by Locus collectively surpass the perforamce of the offical human post-trained Qwen3 1.7B model. In a test of generalization, we ran Locus on all live Kaggle competitions with prize money and public leaderboards. After 16 days, Locus achieved the 4th highest average rank among all participants.

Today we launch the next chapter of Gushwork. Over the last 30 years, we saw commerce moving online - But what actually moved online were low value retail products: books, clothing, electronics. Anything high value, from $5,000 to $1M - a hydraulic crane, an industrial roofing contract, a heat shrink machine - still runs predominantly on human buyer seller conversations. And conversation was the one thing software couldn't do. That just changed. We are bringing 35 million sellers of high value products & services in the physical economy to the agentic web - One of the largest categories of commerce that barely moved online in the internet before AI.

Anthropic has to understand that the days of gate-kept $200/month plans are over kimi k3 dropped its full weight yesterday — the world's first open-weight model in the 2.8T-parameter class MiniMax is expected to follow almost immediately with its own 2-3T open model no moat left

New Anthropic research: Discovering cryptographic weaknesses with Claude. Claude Mythos Preview has helped our researchers find weaknesses in cryptographic algorithms—the mathematical methods that are used to keep data private. Read more:

New in Claude Cowork: teach Claude a skill. Record your screen while you do a task, talk through it as you go, and Claude turns it into a skill it can run again. Find it under Record a skill in the + menu of the Claude desktop app. Available on Pro, Max, and Team plans.